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Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.
Vanaerschot M, Lucantoni L, Li T, Combrinck JM, Ruecker A, Kumar TRS, Rubiano K, Ferreira PE, Siciliano G, Gulati S, Henrich PP, Ng CL, Murithi JM, Corey VC, Duffy S, Lieberman OJ, Veiga MI, Sinden RE, Alano P, Delves MJ, Lee Sim K, Winzeler EA, Egan TJ, Hoffman SL, Avery VM, Fidock DA. Vanaerschot M, et al. Nat Microbiol. 2017 Oct;2(10):1403-1414. doi: 10.1038/s41564-017-0007-4. Epub 2017 Aug 14. Nat Microbiol. 2017. PMID: 28808258 Free PMC article.
Identification of β-hematin inhibitors in the MMV Malaria Box.
Fong KY, Sandlin RD, Wright DW. Fong KY, et al. Int J Parasitol Drugs Drug Resist. 2015 Jun 6;5(3):84-91. doi: 10.1016/j.ijpddr.2015.05.003. eCollection 2015 Dec. Int J Parasitol Drugs Drug Resist. 2015. PMID: 26150923 Free PMC article.
14 results