R01 AI104841/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2013	1
2014	1
2015	2
2016	7
2017	2
2019	3
2022	1
2024	0

1

Antibacterial Antifolates: From Development through Resistance to the Next Generation.

Estrada A, Wright DL, Anderson AC. Estrada A, et al. Cold Spring Harb Perspect Med. 2016 Aug 1;6(8):a028324. doi: 10.1101/cshperspect.a028324. Cold Spring Harb Perspect Med. 2016. PMID: 27352799 Free PMC article. Review.

2

MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.

Reeve SM, Scocchera EW, G-Dayanadan N, Keshipeddy S, Krucinska J, Hajian B, Ferreira J, Nailor M, Aeschlimann J, Wright DL, Anderson AC. Reeve SM, et al. Cell Chem Biol. 2016 Dec 22;23(12):1458-1467. doi: 10.1016/j.chembiol.2016.11.007. Epub 2016 Dec 8. Cell Chem Biol. 2016. PMID: 27939900 Free PMC article.

3

Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.

Krucinska J, Lombardo MN, Erlandsen H, Estrada A, Si D, Viswanathan K, Wright DL. Krucinska J, et al. Commun Biol. 2022 May 13;5(1):459. doi: 10.1038/s42003-022-03384-y. Commun Biol. 2022. PMID: 35562546 Free PMC article.

4

The challenge of resistance in antimicrobial drug development.

Anderson AC, Wright DL. Anderson AC, et al. Future Microbiol. 2015;10(11):1709-10. doi: 10.2217/fmb.15.75. Future Microbiol. 2015. PMID: 26597424 Free PMC article. No abstract available.

5

Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Wright DL, Anderson AC. Lombardo MN, et al. ACS Infect Dis. 2016 Feb 12;2(2):149-56. doi: 10.1021/acsinfecdis.5b00129. Epub 2016 Jan 4. ACS Infect Dis. 2016. PMID: 27624966 Free PMC article.

6

Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis.

Hajian B, Scocchera E, Keshipeddy S, G-Dayanandan N, Shoen C, Krucinska J, Reeve S, Cynamon M, Anderson AC, Wright DL. Hajian B, et al. PLoS One. 2016 Aug 31;11(8):e0161740. doi: 10.1371/journal.pone.0161740. eCollection 2016. PLoS One. 2016. PMID: 27580226 Free PMC article.

7

Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents.

Hajian B, Scocchera E, Shoen C, Krucinska J, Viswanathan K, G-Dayanandan N, Erlandsen H, Estrada A, Mikušová K, Korduláková J, Cynamon M, Wright D. Hajian B, et al. Cell Chem Biol. 2019 Jun 20;26(6):781-791.e6. doi: 10.1016/j.chembiol.2019.02.013. Epub 2019 Mar 28. Cell Chem Biol. 2019. PMID: 30930162 Free PMC article.

8

Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.

Keshipeddy S, Reeve SM, Anderson AC, Wright DL. Keshipeddy S, et al. J Am Chem Soc. 2015 Jul 22;137(28):8983-90. doi: 10.1021/jacs.5b01442. Epub 2015 Jul 8. J Am Chem Soc. 2015. PMID: 26098608 Free PMC article.

9

Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates.

Lombardo MN, G-Dayanandan N, Keshipeddy S, Zhou W, Si D, Reeve SM, Alverson J, Barney P, Walker L, Hoody J, Priestley ND, Obach RS, Wright DL. Lombardo MN, et al. Drug Metab Dispos. 2019 Sep;47(9):995-1003. doi: 10.1124/dmd.119.086504. Epub 2019 Jun 14. Drug Metab Dispos. 2019. PMID: 31201212 Free PMC article.

10

Pharmaceutical analysis of a novel propargyl-linked antifolate antibiotic in the mouse.

Hoody J, Alverson JB, Keshipeddy S, Barney PA, Walker L, Anderson AC, Wright DL, Priestley ND. Hoody J, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Apr 15;1051:54-59. doi: 10.1016/j.jchromb.2017.02.026. Epub 2017 Mar 6. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28314188 Free PMC article.

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