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IL-12 Signals through the TCR To Support CD8 Innate Immune Responses.
Goplen NP, Saxena V, Knudson KM, Schrum AG, Gil D, Daniels MA, Zamoyska R, Teixeiro E. Goplen NP, et al. J Immunol. 2016 Sep 15;197(6):2434-43. doi: 10.4049/jimmunol.1600037. Epub 2016 Aug 12. J Immunol. 2016. PMID: 27521342 Free PMC article.
Early expression of mature αβ TCR in CD4-CD8- T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations.
Laffey KG, Stiles RJ, Ludescher MJ, Davis TR, Khwaja SS, Bram RJ, Wettstein PJ, Ramachandran V, Parks CA, Reyes EE, Ferrer A, Canfield JM, Johnson CE, Hammer RD, Gil D, Schrum AG. Laffey KG, et al. Proc Natl Acad Sci U S A. 2022 Jul 5;119(27):e2118529119. doi: 10.1073/pnas.2118529119. Epub 2022 Jun 29. Proc Natl Acad Sci U S A. 2022. PMID: 35767640 Free PMC article.
Breaking tolerance with engineered class I antigen-presenting molecules.
Parks CA, Henning KR, Pavelko KD, Hansen MJ, Van Keulen VP, Reed BK, Stone JD, Schrum AG, Gil D, Kranz DM, Bordner AJ, Barry MA, Pease LR. Parks CA, et al. Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3136-3145. doi: 10.1073/pnas.1807465116. Epub 2019 Feb 6. Proc Natl Acad Sci U S A. 2019. PMID: 30728302 Free PMC article.
The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network.
Neier SC, Ferrer A, Wilton KM, Smith SEP, Kelcher AMH, Pavelko KD, Canfield JM, Davis TR, Stiles RJ, Chen Z, McCluskey J, Burrows SR, Rossjohn J, Hebrink DM, Carmona EM, Limper AH, Kappes DJ, Wettstein PJ, Johnson AJ, Pease LR, Daniels MA, Neuhauser C, Gil D, Schrum AG. Neier SC, et al. Sci Immunol. 2019 Feb 15;4(32):eaal2201. doi: 10.1126/sciimmunol.aal2201. Sci Immunol. 2019. PMID: 30770409 Free PMC article.