R01 AG063831/AG/NIA NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2016	1
2019	1
2020	5
2021	3
2022	3
2023	1
2024	0

1

Small Molecule Inhibitors Targeting Biosynthesis of Ceramide, the Central Hub of the Sphingolipid Network.

Skácel J, Slusher BS, Tsukamoto T. Skácel J, et al. J Med Chem. 2021 Jan 14;64(1):279-297. doi: 10.1021/acs.jmedchem.0c01664. Epub 2021 Jan 4. J Med Chem. 2021. PMID: 33395289 Free PMC article. Review.

2

Leveraging the interplay of nanotechnology and neuroscience: Designing new avenues for treating central nervous system disorders.

Smith ES, Porterfield JE, Kannan RM. Smith ES, et al. Adv Drug Deliv Rev. 2019 Aug;148:181-203. doi: 10.1016/j.addr.2019.02.009. Epub 2019 Mar 4. Adv Drug Deliv Rev. 2019. PMID: 30844410 Free PMC article. Review.

3

Nipping disease in the bud: nSMase2 inhibitors as therapeutics in extracellular vesicle-mediated diseases.

Tallon C, Hollinger KR, Pal A, Bell BJ, Rais R, Tsukamoto T, Witwer KW, Haughey NJ, Slusher BS. Tallon C, et al. Drug Discov Today. 2021 Jul;26(7):1656-1668. doi: 10.1016/j.drudis.2021.03.025. Epub 2021 Mar 31. Drug Discov Today. 2021. PMID: 33798648 Free PMC article. Review.

4

Inhibition of neutral sphingomyelinase 2 promotes remyelination.

Yoo SW, Agarwal A, Smith MD, Khuder SS, Baxi EG, Thomas AG, Rojas C, Moniruzzaman M, Slusher BS, Bergles DE, Calabresi PA, Haughey NJ. Yoo SW, et al. Sci Adv. 2020 Oct 2;6(40):eaba5210. doi: 10.1126/sciadv.aba5210. Print 2020 Oct. Sci Adv. 2020. PMID: 33008902 Free PMC article.

5

Discovery of Orally Bioavailable and Brain-Penetrable Prodrugs of the Potent nSMase2 Inhibitor DPTIP.

Pal A, Gori S, Yoo SW, Thomas AG, Wu Y, Friedman J, Tenora L, Bhasin H, Alt J, Haughey N, Slusher BS, Rais R. Pal A, et al. J Med Chem. 2022 Aug 25;65(16):11111-11125. doi: 10.1021/acs.jmedchem.2c00562. Epub 2022 Aug 5. J Med Chem. 2022. PMID: 35930706 Free PMC article.

6

Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice.

Huang M, Tallon C, Zhu X, Huizar KDJ, Picciolini S, Thomas AG, Tenora L, Liyanage W, Rodà F, Gualerzi A, Kannan RM, Bedoni M, Rais R, Slusher BS. Huang M, et al. Pharmaceutics. 2023 Sep 21;15(9):2364. doi: 10.3390/pharmaceutics15092364. Pharmaceutics. 2023. PMID: 37765332 Free PMC article.

7

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease.

Šála M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, Lovell L, Kögler M, Hřebabecký H, Procházková E, Nešuta O, Donoghue A, Lam J, Rais R, Rojas C, Slusher BS, Nencka R. Šála M, et al. J Med Chem. 2020 Jun 11;63(11):6028-6056. doi: 10.1021/acs.jmedchem.0c00278. Epub 2020 May 27. J Med Chem. 2020. PMID: 32298582 Free PMC article.

8

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice.

Tallon C, Bell BJ, Sharma A, Pal A, Malvankar MM, Thomas AG, Yoo SW, Hollinger KR, Coleman K, Wilkinson EL, Kannan S, Haughey NJ, Kannan RM, Rais R, Slusher BS. Tallon C, et al. Pharmaceutics. 2022 Sep 28;14(10):2066. doi: 10.3390/pharmaceutics14102066. Pharmaceutics. 2022. PMID: 36297501 Free PMC article.

9

Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV.

Zhu X, Hollinger KR, Huang Y, Borjabad A, Kim BH, Arab T, Thomas AG, Moniruzzaman M, Lovell L, Turchinovich A, Witwer KW, Volsky DJ, Haughey NJ, Slusher BS. Zhu X, et al. Neurobiol Dis. 2022 Jul;169:105734. doi: 10.1016/j.nbd.2022.105734. Epub 2022 Apr 21. Neurobiol Dis. 2022. PMID: 35462006 Free PMC article.

10

Targeting Mitochondria in Tumor-Associated Macrophages using a Dendrimer-Conjugated TSPO Ligand that Stimulates Antitumor Signaling in Glioblastoma.

Sharma A, Liaw K, Sharma R, Thomas AG, Slusher BS, Kannan S, Kannan RM. Sharma A, et al. Biomacromolecules. 2020 Sep 14;21(9):3909-3922. doi: 10.1021/acs.biomac.0c01033. Epub 2020 Aug 31. Biomacromolecules. 2020. PMID: 32786523 Free PMC article.

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