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Can Vitamin B12 Assist the Internalization of Antisense LNA Oligonucleotides into Bacteria?
Pereira S, Yao R, Gomes M, Jørgensen PT, Wengel J, Azevedo NF, Sobral Santos R. Pereira S, et al. Antibiotics (Basel). 2021 Apr 3;10(4):379. doi: 10.3390/antibiotics10040379. Antibiotics (Basel). 2021. PMID: 33916701 Free PMC article.
Only 6-9% were detected in the cytosol, which showed to be insufficient for bacterial growth inhibition. These results suggest that the internalization of B(12)-ASO conjugates is strongly affected by the low uptake rate of the B(12) in E. coli and that further studies are …
Only 6-9% were detected in the cytosol, which showed to be insufficient for bacterial growth inhibition. These results suggest that t …
Natural Compounds for Alzheimer's Disease Therapy: A Systematic Review of Preclinical and Clinical Studies.
Andrade S, Ramalho MJ, Loureiro JA, Pereira MDC. Andrade S, et al. Int J Mol Sci. 2019 May 10;20(9):2313. doi: 10.3390/ijms20092313. Int J Mol Sci. 2019. PMID: 31083327 Free PMC article.
The continuous increase of AD incidence demands for an urgent development of effective therapeutic strategies. Despite the extensive research on this disease, only a few drugs able to delay the progression of the disease are currently available. ...
The continuous increase of AD incidence demands for an urgent development of effective therapeutic strategies. Despite the extensive …