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The Hallmarks of Glioblastoma: Heterogeneity, Intercellular Crosstalk and Molecular Signature of Invasiveness and Progression.
Torrisi F, Alberghina C, D'Aprile S, Pavone AM, Longhitano L, Giallongo S, Tibullo D, Di Rosa M, Zappalà A, Cammarata FP, Russo G, Ippolito M, Cuttone G, Li Volti G, Vicario N, Parenti R. Torrisi F, et al. Biomedicines. 2022 Mar 30;10(4):806. doi: 10.3390/biomedicines10040806. Biomedicines. 2022. PMID: 35453557 Free PMC article. Review.
Connexin 43 and Sonic Hedgehog Pathway Interplay in Glioblastoma Cell Proliferation and Migration.
Torrisi F, Alberghina C, Lo Furno D, Zappalà A, Valable S, Li Volti G, Tibullo D, Vicario N, Parenti R. Torrisi F, et al. Biology (Basel). 2021 Aug 12;10(8):767. doi: 10.3390/biology10080767. Biology (Basel). 2021. PMID: 34439999 Free PMC article.
Importantly, inhibition of CX43 channels was able to prevent SMO-induced effects. SHH pathway and CX43 interplay acts inducing tumorigenic program and supporting cell migration, likely representing druggable targets to develop new therapeutic strategies for GBM....
Importantly, inhibition of CX43 channels was able to prevent SMO-induced effects. SHH pathway and CX43 interplay acts inducing tumorigenic …
Microglia and glioblastoma heterocellular interplay sustains tumour growth and proliferation as an off-target effect of radiotherapy.
Alberghina C, Torrisi F, D'Aprile S, Longhitano L, Giallongo S, Scandura G, Mannino G, Mele S, Sabini MG, Cammarata FP, Russo G, Abdelhameed AS, Zappalà A, Lo Furno D, Giuffrida R, Li Volti G, Tibullo D, Vicario N, Parenti R. Alberghina C, et al. Cell Prolif. 2024 Mar 7:e13606. doi: 10.1111/cpr.13606. Online ahead of print. Cell Prolif. 2024. PMID: 38454614