Amyloid β-Peptide Causes the Permanent Activation of CaMKIIα through Its Oxidation.
Picón-Pagès P, Fanlo-Ucar H, Herrera-Fernández V, Ausellé-Bosch S, Galera-López L, Gutiérrez DA, Ozaita A, Álvarez AR, Oliva B, Muñoz FJ.
Picón-Pagès P, et al.
Int J Mol Sci. 2022 Dec 2;23(23):15169. doi: 10.3390/ijms232315169.
Int J Mol Sci. 2022.
PMID: 36499491
Free PMC article.
It is known that Abeta oligomers (oAbeta) induce synaptic loss and impair the formation of new synapses. Here, we have studied the effects of oAbeta on CaMKIIalpha. We found that oAbeta produce reactive oxygen species (ROS), that induce CaMKIIalpha oxidation in human neuro …
It is known that Abeta oligomers (oAbeta) induce synaptic loss and impair the formation of new synapses. Here, we have studied the effect …