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Gasdermin B over-expression modulates HER2-targeted therapy resistance by inducing protective autophagy through Rab7 activation.
Gámez-Chiachio M, Molina-Crespo Á, Ramos-Nebot C, Martinez-Val J, Martinez L, Gassner K, Llobet FJ, Soriano M, Hernandez A, Cordani M, Bernadó-Morales C, Diaz E, Rojo-Sebastian A, Triviño JC, Sanchez L, Rodríguez-Barrueco R, Arribas J, Llobet-Navás D, Sarrió D, Moreno-Bueno G. Gámez-Chiachio M, et al. J Exp Clin Cancer Res. 2022 Sep 26;41(1):285. doi: 10.1186/s13046-022-02497-w. J Exp Clin Cancer Res. 2022. PMID: 36163066 Free PMC article.
RANK signaling increases after anti-HER2 therapy contributing to the emergence of resistance in HER2-positive breast cancer.
Sanz-Moreno A, Palomeras S, Pedersen K, Morancho B, Pascual T, Galván P, Benítez S, Gomez-Miragaya J, Ciscar M, Jimenez M, Pernas S, Petit A, Soler-Monsó MT, Viñas G, Alsaleem M, Rakha EA, Green AR, Santamaria PG, Mulder C, Lemeer S, Arribas J, Prat A, Puig T, Gonzalez-Suarez E. Sanz-Moreno A, et al. Breast Cancer Res. 2021 Mar 30;23(1):42. doi: 10.1186/s13058-021-01390-2. Breast Cancer Res. 2021. PMID: 33785053 Free PMC article.
The Second Generation Antibody-Drug Conjugate SYD985 Overcomes Resistances to T-DM1.
Nadal-Serrano M, Morancho B, Escrivá-de-Romaní S, Morales CB, Luque A, Escorihuela M, Espinosa Bravo M, Peg V, Dijcks FA, Dokter WHA, Cortés J, Saura C, Arribas J. Nadal-Serrano M, et al. Cancers (Basel). 2020 Mar 13;12(3):670. doi: 10.3390/cancers12030670. Cancers (Basel). 2020. PMID: 32183023 Free PMC article.