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Mineralocorticoid receptor antagonism in diabetes reduces albuminuria by preserving the glomerular endothelial glycocalyx.
Crompton M, Ferguson JK, Ramnath RD, Onions KL, Ogier AS, Gamez M, Down CJ, Skinner L, Wong KH, Dixon LK, Sutak J, Harper SJ, Pontrelli P, Gesualdo L, Heerspink HL, Toto RD, Welsh GI, Foster RR, Satchell SC, Butler MJ. Crompton M, et al. JCI Insight. 2023 Mar 8;8(5):e154164. doi: 10.1172/jci.insight.154164. JCI Insight. 2023. PMID: 36749631 Free PMC article. Clinical Trial.
Heparanase inhibition as a systemic approach to protect the endothelial glycocalyx and prevent microvascular complications in diabetes.
Gamez M, Elhegni HE, Fawaz S, Ho KH, Campbell NW, Copland DA, Onions KL, Butler MJ, Wasson EJ, Crompton M, Ramnath RD, Qiu Y, Yamaguchi Y, Arkill KP, Bates DO, Turnbull JE, Zubkova OV, Welsh GI, Atan D, Satchell SC, Foster RR. Gamez M, et al. Cardiovasc Diabetol. 2024 Feb 1;23(1):50. doi: 10.1186/s12933-024-02133-1. Cardiovasc Diabetol. 2024. PMID: 38302978 Free PMC article.