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Combined Effect of Caspase-Dependent and Caspase-Independent Apoptosis in the Anticancer Activity of Gold Complexes with Phosphine and Benzimidazole Derivatives.
Rouco L, Sánchez-González Á, Alvariño R, Alfonso A, Vázquez-López EM, García-Martínez E, Maneiro M. Rouco L, et al. Pharmaceuticals (Basel). 2020 Dec 24;14(1):10. doi: 10.3390/ph14010010. Pharmaceuticals (Basel). 2020. PMID: 33374177 Free PMC article.
The fluorescence analysis revealed that compounds were inducing apoptosis; however, pre-treatment with the caspase inhibitor Z-VAD did not reduce cell death. Analysis of compound effects on caspase-3 activity and reactive oxygen species (ROS) production in SH-SY5Y cells re …
The fluorescence analysis revealed that compounds were inducing apoptosis; however, pre-treatment with the caspase inhibitor Z-VAD did not r …
Understanding the Factors That Influence the Antioxidant Activity of Manganosalen Complexes with Neuroprotective Effects.
Rouco L, Alvariño R, Alfonso A, Fernández-Fariña S, González-Noya AM, Martínez-Calvo M, Pedrido R, Rodríguez-Silva L, Maneiro M. Rouco L, et al. Antioxidants (Basel). 2024 Feb 22;13(3):265. doi: 10.3390/antiox13030265. Antioxidants (Basel). 2024. PMID: 38539799 Free PMC article.
Manganosalen complexes are a class of catalytic antioxidants with beneficial effects against different neurological disorders according to various in vitro and in vivo studies. ...The antioxidant activity of the new models was tested through superoxide dismutase and catala …
Manganosalen complexes are a class of catalytic antioxidants with beneficial effects against different neurological disorders accordi …