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Page 1
Differential remodeling in small and large murine airways revealed by novel whole lung airway analysis.
Tatler AL, Philp CJ, Hill MR, Cox S, Bullock AM, Habgood A, John A, Middlewick R, Stephenson KE, Goodwin AT, Billington CK, O'Dea RD, Johnson SR, Brook BS. Tatler AL, et al. Am J Physiol Lung Cell Mol Physiol. 2023 Mar 1;324(3):L271-L284. doi: 10.1152/ajplung.00034.2022. Epub 2023 Jan 3. Am J Physiol Lung Cell Mol Physiol. 2023. PMID: 36594851 Free PMC article.
DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.
Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe AJ, Chachi L, Biddle MS, Kaur D, Bourne M, Pavord ID, Wardlaw AJ, Siddiqui SH, Kay RA, Brook BS, Smallwood RH, Brightling CE. Saunders R, et al. Sci Transl Med. 2019 Feb 13;11(479):eaao6451. doi: 10.1126/scitranslmed.aao6451. Sci Transl Med. 2019. PMID: 30760581 Free article. Clinical Trial.
In vitro, in silico and in vivo study challenges the impact of bronchial thermoplasty on acute airway smooth muscle mass loss.
Chernyavsky IL, Russell RJ, Saunders RM, Morris GE, Berair R, Singapuri A, Chachi L, Mansur AH, Howarth PH, Dennison P, Chaudhuri R, Bicknell S, Rose FRAJ, Siddiqui S, Brook BS, Brightling CE. Chernyavsky IL, et al. Eur Respir J. 2018 May 24;51(5):1701680. doi: 10.1183/13993003.01680-2017. Print 2018 May. Eur Respir J. 2018. PMID: 29700102 Free PMC article.