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Trim21 deficiency in mice increases HCC carcinogenesis in a NASH context and is associated with immune checkpoint upregulation.
Kara-Ali GH, Cano L, Dion S, Imerzoukene G, Hamon A, Simoes Eugénio M, Piquet-Pellorce C, Ghukasyan G, Samson M, Le Seyec J, Dimanche-Boitrel MT. Kara-Ali GH, et al. Int J Cancer. 2024 Jun 1;154(11):1999-2013. doi: 10.1002/ijc.34869. Epub 2024 Feb 3. Int J Cancer. 2024. PMID: 38308587
The downregulation of the E3 ubiquitin ligase TRIM21 has been linked to poor prognosis in different cancers including HCC. In order to investigate the role of TRIM21 in liver cancer progression on NASH, Trim21(+/+) and Trim21(-/-) male mice were injected with strept …
The downregulation of the E3 ubiquitin ligase TRIM21 has been linked to poor prognosis in different cancers including HCC. In order t …