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Microlocalization and clinical significance of stabilin-1+ macrophages in treatment-naïve patients with urothelial carcinoma of the bladder.
Wang B, Huang H, Yang M, Yang W, Liu Z, Hou W, Zeng H, He Z, Lin T, Huang J. Wang B, et al. World J Urol. 2020 Mar;38(3):709-716. doi: 10.1007/s00345-019-02853-0. Epub 2019 Jul 13. World J Urol. 2020. PMID: 31302753 Free PMC article.
PURPOSE: Emerging evidence has shown that macrophages (Mphis) at different tumor sites have diverse clinical attributes. Stabilin-1 is a multi-functional scavenger marker for specialized tumor-associated Mphis. ...Immunohistochemistry and immunofluorescence analyses …
PURPOSE: Emerging evidence has shown that macrophages (Mphis) at different tumor sites have diverse clinical attributes. Stabilin-1 i …
SMYD4 monomethylates PRMT5 and forms a positive feedback loop to promote hepatocellular carcinoma progression.
Zhou Z, Chen Z, Zhou Q, Meng S, Shi J, Mui S, Jiang H, Lin J, He G, Li W, Zhang J, Wang J, He C, Yan Y, Xiao Z. Zhou Z, et al. Cancer Sci. 2024 May;115(5):1587-1601. doi: 10.1111/cas.16139. Epub 2024 Mar 4. Cancer Sci. 2024. PMID: 38438251 Free PMC article.
Both lysine and arginine methyltransferases are thought to be promising therapeutic targets for malignant tumors, yet how these methyltransferases function in malignant tumors, especially hepatocellular carcinoma (HCC), has not been fully elucidated. ...SMYD4 …
Both lysine and arginine methyltransferases are thought to be promising therapeutic targets for malignant tumors, yet how thes …
Programmed death ligand-1 is associated with tumor infiltrating lymphocytes and poorer survival in urothelial cell carcinoma of the bladder.
Wang B, Pan W, Yang M, Yang W, He W, Chen X, Bi J, Jiang N, Huang J, Lin T. Wang B, et al. Cancer Sci. 2019 Feb;110(2):489-498. doi: 10.1111/cas.13887. Epub 2018 Dec 12. Cancer Sci. 2019. PMID: 30548363 Free PMC article.
Drugs blocking programmed death ligand-1 (PD-L1) have shown unprecedented activity in metastatic and unresectable bladder cancer. The purpose of the present study was to investigate the expression, clinical significance and association of PD-L1 with tumor-infiltrati …
Drugs blocking programmed death ligand-1 (PD-L1) have shown unprecedented activity in metastatic and unresectable bladder cancer. The purpos …
Integrated Nomograms for Preoperative Prediction of Microvascular Invasion and Lymph Node Metastasis Risk in Hepatocellular Carcinoma Patients.
Yan Y, Zhou Q, Zhang M, Liu H, Lin J, Liu Q, Shi B, Wen K, Chen R, Wang J, Mao K, Xiao Z. Yan Y, et al. Ann Surg Oncol. 2020 May;27(5):1361-1371. doi: 10.1245/s10434-019-08071-7. Epub 2019 Nov 26. Ann Surg Oncol. 2020. PMID: 31773517
RESULTS: The risk factors for MVI were hepatitis B virus (HBV) DNA loading, portal hypertension, Barcelona liver clinic (BCLC) stage, and three computerized tomography (CT) imaging features, namely tumor number, size, and encapsulation, while only BCLC stage, Child-Pugh cl …
RESULTS: The risk factors for MVI were hepatitis B virus (HBV) DNA loading, portal hypertension, Barcelona liver clinic (BCLC) stage, and th …
Intravesical Pseudomonas aeruginosa mannose-sensitive Hemagglutinin vaccine triggers a tumor-preventing immune environment in an orthotopic mouse bladder cancer model.
Wang B, He Z, Yu H, Ou Z, Chen J, Yang M, Fan X, Lin T, Huang J. Wang B, et al. Cancer Immunol Immunother. 2022 Jun;71(6):1507-1517. doi: 10.1007/s00262-021-03063-7. Epub 2021 Oct 31. Cancer Immunol Immunother. 2022. PMID: 34718847 Free PMC article.
However, in tumor-bearing mice after treatment, the increased proportion of Mo-MDSCs and high expression of PD-L1 might be involved in treatment failure. ...The results demonstrated mechanisms underlying intravesical PA-MSHA therapy, pointing at its potential …
However, in tumor-bearing mice after treatment, the increased proportion of Mo-MDSCs and high expression of PD-L1 might be inv …
Integrated analysis reveals an aspartate metabolism-related gene signature for predicting the overall survival in patients with hepatocellular carcinoma.
Shi J, Wen K, Mui S, Li H, Liao H, He C, Yan Y, Zhou Z, Xiao Z. Shi J, et al. Clin Transl Oncol. 2024 Mar 12. doi: 10.1007/s12094-024-03431-6. Online ahead of print. Clin Transl Oncol. 2024. PMID: 38472558
Gene set enrichment analysis and immune infiltration analysis were operated to determine the potential mechanisms underlying the AMGS. ...RESULTS: Patients in the high-AMGS subgroup exerted advanced tumor status and poor prognosis. Mechanistically, the high-AMGS sub …
Gene set enrichment analysis and immune infiltration analysis were operated to determine the potential mechanisms underlying the AMGS …