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Insights into neuroepigenetics through human histone deacetylase PET imaging.
Wey HY, Gilbert TM, Zürcher NR, She A, Bhanot A, Taillon BD, Schroeder FA, Wang C, Haggarty SJ, Hooker JM. Wey HY, et al. Sci Transl Med. 2016 Aug 10;8(351):351ra106. doi: 10.1126/scitranslmed.aaf7551. Sci Transl Med. 2016. PMID: 27510902 Free PMC article. Clinical Trial.
A regularized full reference tissue model for PET neuroreceptor mapping.
Mandeville JB, Sander CYM, Wey HY, Hooker JM, Hansen HD, Svarer C, Knudsen GM, Rosen BR. Mandeville JB, et al. Neuroimage. 2016 Oct 1;139:405-414. doi: 10.1016/j.neuroimage.2016.06.044. Epub 2016 Jun 27. Neuroimage. 2016. PMID: 27364474 Free PMC article.
PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.
Schroeder FA, Wang C, Van de Bittner GC, Neelamegam R, Takakura WR, Karunakaran A, Wey HY, Reis SA, Gale J, Zhang YL, Holson EB, Haggarty SJ, Hooker JM. Schroeder FA, et al. ACS Chem Neurosci. 2014 Oct 15;5(10):1055-62. doi: 10.1021/cn500162j. Epub 2014 Sep 19. ACS Chem Neurosci. 2014. PMID: 25188794 Free PMC article.