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HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies.
Expert Rev Anticancer Ther. 2011 Feb;11(2):263-75. doi: 10.1586/era.10.226.
Expert Rev Anticancer Ther. 2011.
PMID: 21342044
Free PMC article.
Review.
AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.
Chandarlapaty S, Sawai A, Scaltriti M, Rodrik-Outmezguine V, Grbovic-Huezo O, Serra V, Majumder PK, Baselga J, Rosen N.
Chandarlapaty S, et al.
Cancer Cell. 2011 Jan 18;19(1):58-71. doi: 10.1016/j.ccr.2010.10.031. Epub 2011 Jan 6.
Cancer Cell. 2011.
PMID: 21215704
Free PMC article.
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PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer.
Serra V, Scaltriti M, Prudkin L, Eichhorn PJ, Ibrahim YH, Chandarlapaty S, Markman B, Rodriguez O, Guzman M, Rodriguez S, Gili M, Russillo M, Parra JL, Singh S, Arribas J, Rosen N, Baselga J.
Serra V, et al.
Oncogene. 2011 Jun 2;30(22):2547-57. doi: 10.1038/onc.2010.626. Epub 2011 Jan 31.
Oncogene. 2011.
PMID: 21278786
Free PMC article.
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