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Population Pharmacokinetic Analysis and Dosing Optimization of Sirolimus in Children With Tuberous Sclerosis Complex.
Li S, Zhan M, Wu S, Liao J, Xu H, Sun D, Zhao X, Wang Y. Li S, et al. J Clin Pharmacol. 2022 Aug;62(8):948-959. doi: 10.1002/jcph.2033. Epub 2022 Mar 2. J Clin Pharmacol. 2022. PMID: 35094415
A total of 64 children were recruited in this multicenter, retrospective pharmacokinetic study. Whole-blood concentrations of sirolimus, demographic, and clinical information were collected and analyzed using a nonlinear mixed-effects population modeling method. ...
A total of 64 children were recruited in this multicenter, retrospective pharmacokinetic study. Whole-blood concentrations of sirolimus, dem …