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2023 6
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Kinin B1 and B2 Receptors Contribute to Cisplatin-Induced Painful Peripheral Neuropathy in Male Mice.
Becker G, Fialho MFP, Brusco I, Oliveira SM. Becker G, et al. Pharmaceutics. 2023 Mar 6;15(3):852. doi: 10.3390/pharmaceutics15030852. Pharmaceutics. 2023. PMID: 36986713 Free PMC article.
Cisplatin is the preferential chemotherapeutic drug for highly prevalent solid tumours. However, its clinical efficacy is frequently limited due to neurotoxic effects such as peripheral neuropathy. ...
Cisplatin is the preferential chemotherapeutic drug for highly prevalent solid tumours. However, its clinical efficacy is frequently …
G Protein-Coupled Receptors and Ion Channels Involvement in Cisplatin-Induced Peripheral Neuropathy: A Review of Preclinical Studies.
Becker G, Atuati SF, Oliveira SM. Becker G, et al. Cancers (Basel). 2024 Jan 30;16(3):580. doi: 10.3390/cancers16030580. Cancers (Basel). 2024. PMID: 38339331 Free PMC article. Review.
Cisplatin is a platinum-based chemotherapy drug widely used to treat various solid tumours. Although it is effective in anti-cancer therapy, many patients develop peripheral neuropathy during and after cisplatin treatment. ...In recent years, preclinical studies have been …
Cisplatin is a platinum-based chemotherapy drug widely used to treat various solid tumours. Although it is effective in anti-cancer t …
TRPV4 Activation and its Intracellular Modulation Mediated by Kinin Receptors Contribute to Painful Symptoms Induced by Anastrozole.
Fialho MFP, Brum ES, Becker G, Oliveira SM. Fialho MFP, et al. Mol Neurobiol. 2024 Mar;61(3):1627-1642. doi: 10.1007/s12035-023-03654-8. Epub 2023 Sep 23. Mol Neurobiol. 2024. PMID: 37740866
In animals previously treated with anastrozole, the local administration of sub-nociceptive doses of the TRPV4 (4alpha-PDD or hypotonic solution), B(2)R (Bradykinin) or B(1)R (DABk) agonists enhanced the anastrozole-induced pain behaviours. The sensitizing effects induced …
In animals previously treated with anastrozole, the local administration of sub-nociceptive doses of the TRPV4 (4alpha-PDD or hypotonic solu …
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice.
Marquezin LP, Fialho MFP, Favarin A, de Lara JD, Pillat MM, Rosemberg DB, Oliveira SM. Marquezin LP, et al. Inflammopharmacology. 2024 Apr 25. doi: 10.1007/s10787-024-01473-4. Online ahead of print. Inflammopharmacology. 2024. PMID: 38662182
Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorbidities such as fatigue, anxiety, and depression. Current therapeutic approaches present adverse effects that limit adherence to therapy. Diosmetin, an …
Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorbidities such as fa …
The Association of Oleic Acid and Dexamethasone Acetate into Nanocapsules Enables a Reduction in the Effective Corticosteroid Dose in a UVB Radiation-Induced Sunburn Model in Mice.
Pegoraro NS, Gehrcke M, Camponogara C, Fialho MFP, Cruz L, Oliveira SM. Pegoraro NS, et al. Pharmaceutics. 2024 Jan 26;16(2):176. doi: 10.3390/pharmaceutics16020176. Pharmaceutics. 2024. PMID: 38399236 Free PMC article.
However, its use is related to the rebound effect, rosacea, purple, and increased blood glucose levels. Nanotechnology approaches have emerged as strategies for drug delivery due to their advantages in improving therapeutic effects. To reduce dexamethasone-related a …
However, its use is related to the rebound effect, rosacea, purple, and increased blood glucose levels. Nanotechnology approaches have emerg …