GM49725/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
1997	3
1999	3
2000	2
2001	3
2003	2
2004	3
2005	2
2006	1
2007	1
2009	7
2010	7
2011	1
2012	2
2013	4
2015	3
2024	0

1

Structural basis for isoform-selective inhibition in nitric oxide synthase.

Poulos TL, Li H. Poulos TL, et al. Acc Chem Res. 2013 Feb 19;46(2):390-8. doi: 10.1021/ar300175n. Epub 2012 Oct 2. Acc Chem Res. 2013. PMID: 23030042 Free PMC article.

2

Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases.

Silverman RB. Silverman RB. Acc Chem Res. 2009 Mar 17;42(3):439-51. doi: 10.1021/ar800201v. Acc Chem Res. 2009. PMID: 19154146 Free PMC article. Review.

3

Inhibitor Bound Crystal Structures of Bacterial Nitric Oxide Synthase.

Holden JK, Dejam D, Lewis MC, Huang H, Kang S, Jing Q, Xue F, Silverman RB, Poulos TL. Holden JK, et al. Biochemistry. 2015 Jul 7;54(26):4075-82. doi: 10.1021/acs.biochem.5b00431. Epub 2015 Jun 23. Biochemistry. 2015. PMID: 26062720 Free PMC article.

4

Structure-based design of bacterial nitric oxide synthase inhibitors.

Holden JK, Kang S, Hollingsworth SA, Li H, Lim N, Chen S, Huang H, Xue F, Tang W, Silverman RB, Poulos TL. Holden JK, et al. J Med Chem. 2015 Jan 22;58(2):994-1004. doi: 10.1021/jm501723p. Epub 2015 Jan 6. J Med Chem. 2015. PMID: 25522110 Free PMC article.

5

Structural and biological studies on bacterial nitric oxide synthase inhibitors.

Holden JK, Li H, Jing Q, Kang S, Richo J, Silverman RB, Poulos TL. Holden JK, et al. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18127-31. doi: 10.1073/pnas.1314080110. Epub 2013 Oct 21. Proc Natl Acad Sci U S A. 2013. PMID: 24145412 Free PMC article.

6

Crystal structures of constitutive nitric oxide synthases in complex with de novo designed inhibitors.

Igarashi J, Li H, Jamal J, Ji H, Fang J, Lawton GR, Silverman RB, Poulos TL. Igarashi J, et al. J Med Chem. 2009 Apr 9;52(7):2060-6. doi: 10.1021/jm900007a. J Med Chem. 2009. PMID: 19296678 Free PMC article.

7

Imidazole-containing amino acids as selective inhibitors of nitric oxide synthases.

Lee Y, Martasek P, Roman LJ, Masters BS, Silverman RB. Lee Y, et al. Bioorg Med Chem. 1999 Sep;7(9):1941-51. doi: 10.1016/s0968-0896(99)00117-0. Bioorg Med Chem. 1999. PMID: 10530943

8

Model studies for heme oxygenase-catalyzed porphyrin meso hydroxylation.

Zhu Y, Silverman RB. Zhu Y, et al. Org Lett. 2007 Mar 29;9(7):1195-8. doi: 10.1021/ol063088f. Epub 2007 Mar 8. Org Lett. 2007. PMID: 17343390

9

Structure-based design, synthesis, and biological evaluation of lipophilic-tailed monocationic inhibitors of neuronal nitric oxide synthase.

Xue F, Huang J, Ji H, Fang J, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Xue F, et al. Bioorg Med Chem. 2010 Sep 1;18(17):6526-37. doi: 10.1016/j.bmc.2010.06.074. Epub 2010 Jul 1. Bioorg Med Chem. 2010. PMID: 20673724 Free PMC article.

10

Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase.

Li H, Xue F, Kraus JM 2nd, Ji H, Labby KJ, Mataka J, Delker SL, Martásek P, Roman LJ, Poulos TL, Silverman RB. Li H, et al. Bioorg Med Chem. 2013 Mar 1;21(5):1333-43. doi: 10.1016/j.bmc.2012.12.019. Epub 2012 Dec 22. Bioorg Med Chem. 2013. PMID: 23352768 Free PMC article.

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