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Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response.
Behrendt R, Schumann T, Gerbaulet A, Nguyen LA, Schubert N, Alexopoulou D, Berka U, Lienenklaus S, Peschke K, Gibbert K, Wittmann S, Lindemann D, Weiss S, Dahl A, Naumann R, Dittmer U, Kim B, Mueller W, Gramberg T, Roers A. Behrendt R, et al. Cell Rep. 2013 Aug 29;4(4):689-96. doi: 10.1016/j.celrep.2013.07.037. Epub 2013 Aug 22. Cell Rep. 2013. PMID: 23972988 Free PMC article.
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.
Baldauf HM, Pan X, Erikson E, Schmidt S, Daddacha W, Burggraf M, Schenkova K, Ambiel I, Wabnitz G, Gramberg T, Panitz S, Flory E, Landau NR, Sertel S, Rutsch F, Lasitschka F, Kim B, König R, Fackler OT, Keppler OT. Baldauf HM, et al. Nat Med. 2012 Nov;18(11):1682-7. doi: 10.1038/nm.2964. Nat Med. 2012. PMID: 22972397 Free PMC article.