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Presenilin-1 Targeted Morpholino Induces Cognitive Deficits, Increased Brain Aβ1-42 and Decreased Synaptic Marker PSD-95 in Zebrafish Larvae.
Nery LR, Silva NE, Fonseca R, Vianna MRM. Nery LR, et al. Neurochem Res. 2017 Oct;42(10):2959-2967. doi: 10.1007/s11064-017-2327-4. Epub 2017 Jun 16. Neurochem Res. 2017. PMID: 28623607
In our study, we used a morpholino antisense nucleotide that targets exon 8 splicing site of psen1 resulting in a dominant negative protein previously validated to investigate behavioral and molecular effects in 5 days post fertilization (dpf) zebrafish larvae. Morphants s …
In our study, we used a morpholino antisense nucleotide that targets exon 8 splicing site of psen1 resulting in a dominant negative protein …