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Fetal hemoglobin-boosting haplotypes of BCL11A gene and HBS1L-MYB intergenic region in the prediction of clinical and hematological outcomes in a cohort of children with sickle cell anemia.
Sales RR, Nogueira BL, Belisário AR, Faria G, Mendes F, Viana MB, Luizon MR. Sales RR, et al. J Hum Genet. 2022 Dec;67(12):701-709. doi: 10.1038/s10038-022-01079-0. Epub 2022 Sep 27. J Hum Genet. 2022. PMID: 36167770
We examined whether HbF-boosting haplotypes combining alleles of functional SNPs of BCL11A and HMIP-2 were associated with clinical outcomes and hematological parameters, and whether they interact to regulate HbF in a cohort of Brazilian children with SCA. ...Our no …
We examined whether HbF-boosting haplotypes combining alleles of functional SNPs of BCL11A and HMIP-2 were associated with clinical o …
CLIMBra - Climate Change Dataset for Brazil.
Ballarin AS, Sone JS, Gesualdo GC, Schwamback D, Reis A, Almagro A, Wendland EC. Ballarin AS, et al. Sci Data. 2023 Jan 20;10(1):47. doi: 10.1038/s41597-023-01956-z. Sci Data. 2023. PMID: 36670117 Free PMC article.
Here, we provide a dataset based on an ensemble of 19 bias-corrected CMIP6 climate models projections for the Brazilian territory based on the SSP2-4.5 and SSP5-8.5 scenarios. We used the Quantile Delta Mapping approach to bias-correct daily time-series of precipitation, m …
Here, we provide a dataset based on an ensemble of 19 bias-corrected CMIP6 climate models projections for the Brazilian territory bas …
Notch pathway in ependymoma RELA-fused subgroup: upregulation and association with cancer stem cells markers expression.
de Almeida Magalhães T, Cruzeiro GAV, de Sousa GR, da Silva KR, Lira RCP, Scrideli CA, Tone LG, Valera ET, Borges KS. de Almeida Magalhães T, et al. Cancer Gene Ther. 2020 Jun;27(6):509-512. doi: 10.1038/s41417-019-0122-x. Epub 2019 Jul 16. Cancer Gene Ther. 2020. PMID: 31308481
Considering the putative role of Notch signaling in the maintenance of the cancer stem cells (CSC) phenotype in RELA-fused EPN, we investigated the expression of Notch pathway and its target genes in this subgroup. We also evaluated the effects of two Notch inhibitors (DAP …
Considering the putative role of Notch signaling in the maintenance of the cancer stem cells (CSC) phenotype in RELA-fused EPN, we investiga …
Aerobic exercise attenuates dysautonomia, cardiac diastolic dysfunctions, and hemodynamic overload in female mice with atherosclerosis.
Nascimento-Carvalho B, da Silva BD, da Silva MB, Dos-Santos A, Ribeiro TF, da Silva Dias D, de Souza LE, Dutra MRH, Catanozi S, Caldini EG, De Angelis K, Scapini KB, Sanches IC, Irigoyen MC. Nascimento-Carvalho B, et al. Sci Rep. 2024 Apr 3;14(1):7835. doi: 10.1038/s41598-024-52883-x. Sci Rep. 2024. PMID: 38570516 Free PMC article.
Positive correlation coefficients were found between aortic wall thickness with hemodynamics data. The aging process causes a series of deleterious effects such as hemodynamic overload and dysautonomia in female with atherosclerosis. ...
Positive correlation coefficients were found between aortic wall thickness with hemodynamics data. The aging process causes a series of dele …