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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA. Mills EL, et al. Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28. Nature. 2018. PMID: 29590092 Free PMC article.
BACE1: More than just a β-secretase.
Taylor HA, Przemylska L, Clavane EM, Meakin PJ. Taylor HA, et al. Obes Rev. 2022 Jul;23(7):e13430. doi: 10.1111/obr.13430. Epub 2022 Feb 4. Obes Rev. 2022. PMID: 35119166 Free PMC article. Review.
Endothelial Cell Fibrin Gel Angiogenesis Bead Assay.
Clavane EM, Taylor HA, Cubbon RM, Meakin PJ. Clavane EM, et al. Methods Mol Biol. 2022;2441:321-327. doi: 10.1007/978-1-0716-2059-5_25. Methods Mol Biol. 2022. PMID: 35099748
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.
Meakin PJ, Coull BM, Tuharska Z, McCaffery C, Akoumianakis I, Antoniades C, Brown J, Griffin KJ, Platt F, Ozber CH, Yuldasheva NY, Makava N, Skromna A, Prescott A, McNeilly AD, Siddiqui M, Palmer CN, Khan F, Ashford ML. Meakin PJ, et al. J Clin Invest. 2020 Aug 3;130(8):4104-4117. doi: 10.1172/JCI122237. J Clin Invest. 2020. PMID: 32407295 Free PMC article.
Corrigendum to "The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling" [Metab Clin Exp 85 (2018) 59-75].
Botteri G, Salvadó L, Gumà A, Hamilton DL, Meakin PJ, Montagut G, Ashford MLJ, Ceperuelo-Mallafré V, Fernández-Veledo S, Vendrell J, Calderón-Dominguez M, Serra D, Herrero L, Pizarro J, Barroso E, Palomer X, Vázquez-Carrera M. Botteri G, et al. Metabolism. 2019 Jul;96:101-102. doi: 10.1016/j.metabol.2019.04.009. Epub 2019 Apr 18. Metabolism. 2019. PMID: 31005247 No abstract available.