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H4K16ac activates the transcription of transposable elements and contributes to their cis-regulatory function.
Nat Struct Mol Biol. 2023 Jul;30(7):935-947. doi: 10.1038/s41594-023-01016-5. Epub 2023 Jun 12.
Nat Struct Mol Biol. 2023.
PMID: 37308596
Free PMC article.
Target-Specific Precision of CRISPR-Mediated Genome Editing.
Chakrabarti AM, Henser-Brownhill T, Monserrat J, Poetsch AR, Luscombe NM, Scaffidi P.
Chakrabarti AM, et al.
Mol Cell. 2019 Feb 21;73(4):699-713.e6. doi: 10.1016/j.molcel.2018.11.031. Epub 2018 Dec 13.
Mol Cell. 2019.
PMID: 30554945
Free PMC article.
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Disruption of the MSL complex inhibits tumour maintenance by exacerbating chromosomal instability.
Monserrat J, Morales Torres C, Richardson L, Wilson TS, Patel H, Domart MC, Horswell S, Song OR, Jiang M, Crawford M, Bui M, Dalal Y, Scaffidi P.
Monserrat J, et al.
Nat Cell Biol. 2021 Apr;23(4):401-412. doi: 10.1038/s41556-021-00657-2. Epub 2021 Apr 9.
Nat Cell Biol. 2021.
PMID: 33837287
Free PMC article.
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Redistribution of EZH2 promotes malignant phenotypes by rewiring developmental programmes.
Mortimer T, Wainwright EN, Patel H, Siow BM, Jaunmuktane Z, Brandner S, Scaffidi P.
Mortimer T, et al.
EMBO Rep. 2019 Oct 4;20(10):e48155. doi: 10.15252/embr.201948155. Epub 2019 Aug 29.
EMBO Rep. 2019.
PMID: 31468686
Free PMC article.
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Selective inhibition of cancer cell self-renewal through a Quisinostat-histone H1.0 axis.
Morales Torres C, Wu MY, Hobor S, Wainwright EN, Martin MJ, Patel H, Grey W, Grönroos E, Howell S, Carvalho J, Snijders AP, Bustin M, Bonnet D, Smith PD, Swanton C, Howell M, Scaffidi P.
Morales Torres C, et al.
Nat Commun. 2020 Apr 14;11(1):1792. doi: 10.1038/s41467-020-15615-z.
Nat Commun. 2020.
PMID: 32286289
Free PMC article.
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CRISPR-based large-scale modeling of loss-of-function mutations to investigate mechanisms of stress resistance in cancer.
Simeoni F, Loukas I, Wilson TS, Scaffidi P.
Simeoni F, et al.
STAR Protoc. 2023 Mar 17;4(1):102097. doi: 10.1016/j.xpro.2023.102097. Epub 2023 Feb 11.
STAR Protoc. 2023.
PMID: 36853711
Free PMC article.
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ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer.
Moreno T, Monterde B, González-Silva L, Betancor-Fernández I, Revilla C, Agraz-Doblas A, Freire J, Isidro P, Quevedo L, Blanco R, Montes-Moreno S, Cereceda L, Astudillo A, Casar B, Crespo P, Morales Torres C, Scaffidi P, Gómez-Román J, Salido E, Varela I.
Moreno T, et al.
Oncogene. 2021 Apr;40(16):2923-2935. doi: 10.1038/s41388-021-01748-y. Epub 2021 Mar 19.
Oncogene. 2021.
PMID: 33742126
Free PMC article.
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