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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1881 1
1901 1
1933 1
1934 1
1935 1
1936 1
1940 1
1946 1
1948 1
1949 1
1950 1
1951 1
1952 2
1953 3
1954 2
1955 1
1956 3
1957 4
1958 2
1959 3
1960 3
1961 4
1962 4
1963 4
1964 8
1965 10
1966 4
1967 9
1968 3
1969 8
1970 8
1971 9
1972 16
1973 40
1974 30
1975 32
1976 20
1977 24
1978 36
1979 46
1980 46
1981 40
1982 38
1983 116
1984 126
1985 79
1986 88
1987 54
1988 82
1989 75
1990 67
1991 54
1992 59
1993 76
1994 60
1995 92
1996 100
1997 124
1998 93
1999 89
2000 112
2001 121
2002 104
2003 129
2004 117
2005 157
2006 156
2007 167
2008 175
2009 189
2010 197
2011 252
2012 258
2013 301
2014 352
2015 443
2016 478
2017 518
2018 684
2019 737
2020 842
2021 1004
2022 1060
2023 1237
2024 626

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11,336 results

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Page 1
Design of experiments (DoE) in pharmaceutical development.
N Politis S, Colombo P, Colombo G, M Rekkas D. N Politis S, et al. Drug Dev Ind Pharm. 2017 Jun;43(6):889-901. doi: 10.1080/03639045.2017.1291672. Epub 2017 Feb 23. Drug Dev Ind Pharm. 2017. PMID: 28166428 Review.
Among various mathematical modeling approaches, Design of Experiments (DoE) is extensively used for the implementation of QbD in both research and industrial settings. ...This review illustrates the principles of quality theory through the work of major contributors, the e …
Among various mathematical modeling approaches, Design of Experiments (DoE) is extensively used for the implementation of QbD in both …
A General Guide for the Optimization of Enzyme Assay Conditions Using the Design of Experiments Approach.
Onyeogaziri FC, Papaneophytou C. Onyeogaziri FC, et al. SLAS Discov. 2019 Jun;24(5):587-596. doi: 10.1177/2472555219830084. Epub 2019 Feb 25. SLAS Discov. 2019. PMID: 30802413 Free article.
The process of an enzyme assay optimization, in our experience, can take more than 12 weeks using the traditional one-factor-at-a-time approach. In contrast, the design of experiments (DoE) approaches have the potential to speed up the assay optimization process and provid …
The process of an enzyme assay optimization, in our experience, can take more than 12 weeks using the traditional one-factor-at-a-time appro …
Chronotropic incompetence demonstrated with cardiopulmonary exercise test.
Lønnee MF, Carstensen HG, Jensen MR. Lønnee MF, et al. Ugeskr Laeger. 2024 Feb 26;186(9):V09230566. doi: 10.61409/V09230566. Ugeskr Laeger. 2024. PMID: 38445323 Free article. Danish.
In his case report, a 74-year-old physically fit man was evaluated repeatedly for several years in the cardiology department due to dyspnoea on exertion (DOE). Several standard cardiac and pulmonary tests were performed but did not provide sufficient cause for the DOE …
In his case report, a 74-year-old physically fit man was evaluated repeatedly for several years in the cardiology department due to dyspnoea …
Dyspnea during exercise and voluntary hyperpnea in women with obesity.
Spencer MD, Balmain BN, Bernhardt V, Wilhite DP, Babb TG. Spencer MD, et al. Respir Physiol Neurobiol. 2021 May;287:103638. doi: 10.1016/j.resp.2021.103638. Epub 2021 Feb 11. Respir Physiol Neurobiol. 2021. PMID: 33581294 Free PMC article.
RPB increased with ventilation during constant-load (+DOE: R(2)=0.86; -DOE: R(2)=0.82) and incremental (+DOE: R(2)=0.91; -DOE: R(2)=0.92) exercise, but + DOE had a greater y-intercept than -DOE (60W: -0.161.53 vs. -0.730.55; incremental: …
RPB increased with ventilation during constant-load (+DOE: R(2)=0.86; -DOE: R(2)=0.82) and incremental (+DOE: R(2)=0.91 …
Design of experiment techniques for the optimization of chromatographic analysis conditions: A review.
Peng L, Gao X, Wang L, Zhu A, Cai X, Li P, Li W. Peng L, et al. Electrophoresis. 2022 Oct;43(18-19):1882-1898. doi: 10.1002/elps.202200072. Epub 2022 Jul 18. Electrophoresis. 2022. PMID: 35848309 Review.
Design of experiment (DoE) techniques have been widely used in the field of chromatographic parameters optimization as a valuable tool. A systematic literature review of the available DoE techniques applied to the development of a chromatographic analysis method is …
Design of experiment (DoE) techniques have been widely used in the field of chromatographic parameters optimization as a valuable too …
Statistical Design of Experiments for Synthetic Biology.
Gilman J, Walls L, Bandiera L, Menolascina F. Gilman J, et al. ACS Synth Biol. 2021 Jan 15;10(1):1-18. doi: 10.1021/acssynbio.0c00385. Epub 2021 Jan 7. ACS Synth Biol. 2021. PMID: 33406821 Review.
To address these limitations, an increasing number of studies have turned to Design of Experiments (DoE), a suite of methods that enable efficient, systematic exploration and exploitation of complex design spaces. This review provides an overview of DoE for syntheti …
To address these limitations, an increasing number of studies have turned to Design of Experiments (DoE), a suite of methods that ena …
Optimizing Mass Spectrometry Analyses: A Tailored Review on the Utility of Design of Experiments.
Hecht ES, Oberg AL, Muddiman DC. Hecht ES, et al. J Am Soc Mass Spectrom. 2016 May;27(5):767-85. doi: 10.1007/s13361-016-1344-x. Epub 2016 Mar 7. J Am Soc Mass Spectrom. 2016. PMID: 26951559 Free PMC article. Review.
Performance of both off-line and MS methods can be optimized separately or, when appropriate, simultaneously through statistical designs, broadly referred to as "design of experiments" (DOE). The following review provides a tutorial-like guide into the selection of DOE …
Performance of both off-line and MS methods can be optimized separately or, when appropriate, simultaneously through statistical designs, br …
Clever Experimental Designs: Shortcuts for Better iPSC Differentiation.
Yasui R, Sekine K, Taniguchi H. Yasui R, et al. Cells. 2021 Dec 15;10(12):3540. doi: 10.3390/cells10123540. Cells. 2021. PMID: 34944048 Free PMC article. Review.
Although DOE has become routinely utilized in the bioengineering and pharmaceutical fields, the imminent need of more detailed cell-lineage specification, complex organoid construction, and a stable supply of qualified cell-derived material requires expedition of DOE …
Although DOE has become routinely utilized in the bioengineering and pharmaceutical fields, the imminent need of more detailed cell-l …
Design of experiments in the optimization of nanoparticle-based drug delivery systems.
Rampado R, Peer D. Rampado R, et al. J Control Release. 2023 Jun;358:398-419. doi: 10.1016/j.jconrel.2023.05.001. Epub 2023 May 12. J Control Release. 2023. PMID: 37164240 Review.
Design of experiment (DoE) is a powerful statistical technique used for variable screening and optimization. ...First, we introduce general principles of DoE to the reader, which are indispensable to understand the works we report. ...
Design of experiment (DoE) is a powerful statistical technique used for variable screening and optimization. ...First, we introduce g …
Design of Experiments in metabolomics-related studies: An overview.
Jacyna J, Kordalewska M, Markuszewski MJ. Jacyna J, et al. J Pharm Biomed Anal. 2019 Feb 5;164:598-606. doi: 10.1016/j.jpba.2018.11.027. Epub 2018 Nov 13. J Pharm Biomed Anal. 2019. PMID: 30469109 Review.
Therefore, in this short overview, apart from summarizing some basic concepts of DoE, we wanted to provide a guideline for those who are about to plan metabolomics-related experiments. ...In addition to the first section, which will introduce the history and basics of D …
Therefore, in this short overview, apart from summarizing some basic concepts of DoE, we wanted to provide a guideline for those who …
11,336 results
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