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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1881 1
1901 1
1933 1
1934 1
1935 1
1936 1
1940 1
1946 1
1948 1
1949 1
1950 1
1951 1
1952 2
1953 3
1954 2
1955 1
1956 3
1957 4
1958 2
1959 3
1960 3
1961 4
1962 4
1963 4
1964 8
1965 10
1966 4
1967 9
1968 3
1969 8
1970 8
1971 9
1972 16
1973 40
1974 30
1975 32
1976 20
1977 24
1978 36
1979 46
1980 46
1981 40
1982 38
1983 116
1984 126
1985 79
1986 88
1987 54
1988 82
1989 75
1990 67
1991 54
1992 59
1993 76
1994 60
1995 92
1996 100
1997 124
1998 93
1999 89
2000 112
2001 121
2002 104
2003 129
2004 117
2005 157
2006 156
2007 167
2008 175
2009 189
2010 197
2011 252
2012 258
2013 301
2014 352
2015 443
2016 478
2017 518
2018 684
2019 736
2020 842
2021 1000
2022 1060
2023 1235
2024 583

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11,287 results

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Page 1
Design of experiments (DoE) in pharmaceutical development.
N Politis S, Colombo P, Colombo G, M Rekkas D. N Politis S, et al. Drug Dev Ind Pharm. 2017 Jun;43(6):889-901. doi: 10.1080/03639045.2017.1291672. Epub 2017 Feb 23. Drug Dev Ind Pharm. 2017. PMID: 28166428 Review.
Among various mathematical modeling approaches, Design of Experiments (DoE) is extensively used for the implementation of QbD in both research and industrial settings. ...This review illustrates the principles of quality theory through the work of major contributors …
Among various mathematical modeling approaches, Design of Experiments (DoE) is extensively used for the implementation of QbD in both …
A General Guide for the Optimization of Enzyme Assay Conditions Using the Design of Experiments Approach.
Onyeogaziri FC, Papaneophytou C. Onyeogaziri FC, et al. SLAS Discov. 2019 Jun;24(5):587-596. doi: 10.1177/2472555219830084. Epub 2019 Feb 25. SLAS Discov. 2019. PMID: 30802413 Free article.
The process of an enzyme assay optimization, in our experience, can take more than 12 weeks using the traditional one-factor-at-a-time approach. In contrast, the design of experiments (DoE) approaches have the potential to speed up the assay optimization process and provid …
The process of an enzyme assay optimization, in our experience, can take more than 12 weeks using the traditional one-factor-at-a-time appro …
LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants.
Westendorf K, Žentelis S, Wang L, Foster D, Vaillancourt P, Wiggin M, Lovett E, van der Lee R, Hendle J, Pustilnik A, Sauder JM, Kraft L, Hwang Y, Siegel RW, Chen J, Heinz BA, Higgs RE, Kallewaard NL, Jepson K, Goya R, Smith MA, Collins DW, Pellacani D, Xiang P, de Puyraimond V, Ricicova M, Devorkin L, Pritchard C, O'Neill A, Dalal K, Panwar P, Dhupar H, Garces FA, Cohen CA, Dye JM, Huie KE, Badger CV, Kobasa D, Audet J, Freitas JJ, Hassanali S, Hughes I, Munoz L, Palma HC, Ramamurthy B, Cross RW, Geisbert TW, Menachery V, Lokugamage K, Borisevich V, Lanz I, Anderson L, Sipahimalani P, Corbett KS, Yang ES, Zhang Y, Shi W, Zhou T, Choe M, Misasi J, Kwong PD, Sullivan NJ, Graham BS, Fernandez TL, Hansen CL, Falconer E, Mascola JR, Jones BE, Barnhart BC. Westendorf K, et al. Cell Rep. 2022 May 17;39(7):110812. doi: 10.1016/j.celrep.2022.110812. Epub 2022 Apr 25. Cell Rep. 2022. PMID: 35568025 Free PMC article.
Finned zeolite catalysts.
Dai H, Shen Y, Yang T, Lee C, Fu D, Agarwal A, Le TT, Tsapatsis M, Palmer JC, Weckhuysen BM, Dauenhauer PJ, Zou X, Rimer JD. Dai H, et al. Nat Mater. 2020 Oct;19(10):1074-1080. doi: 10.1038/s41563-020-0753-1. Epub 2020 Aug 10. Nat Mater. 2020. PMID: 32778812
Triple ionic-electronic conducting oxides for next-generation electrochemical devices.
Papac M, Stevanović V, Zakutayev A, O'Hayre R. Papac M, et al. Nat Mater. 2021 Mar;20(3):301-313. doi: 10.1038/s41563-020-00854-8. Epub 2020 Dec 21. Nat Mater. 2021. PMID: 33349671 Review.
We particularly focus on the discovery criteria (for example, crystal structure and ion electronegativity), design principles (for example, cation and anion substitution chemistry) and operating conditions (for example, atmosphere) of materials that enable deliberate tuning of th …
We particularly focus on the discovery criteria (for example, crystal structure and ion electronegativity), design principles (for example, …
Design of experiments (DoE) to develop and to optimize nanoparticles as drug delivery systems.
Tavares Luiz M, Santos Rosa Viegas J, Palma Abriata J, Viegas F, Testa Moura de Carvalho Vicentini F, Lopes Badra Bentley MV, Chorilli M, Maldonado Marchetti J, Tapia-Blácido DR. Tavares Luiz M, et al. Eur J Pharm Biopharm. 2021 Aug;165:127-148. doi: 10.1016/j.ejpb.2021.05.011. Epub 2021 May 13. Eur J Pharm Biopharm. 2021. PMID: 33992754 Review.
In this context, quality-oriented manufacturing of nanoparticles has been an important strategy to understand and to optimize the factors involved in their production. For this purpose, Design of Experiment (DoE) tools have been applied to obtain enough knowledge about the …
In this context, quality-oriented manufacturing of nanoparticles has been an important strategy to understand and to optimize the factors in …
U.S. Department of Energy policies, directives, and guidance for radiological control and release of property.
Wallo A, Domotor S, Vázquez G. Wallo A, et al. Health Phys. 2006 Nov;91(5):526-8. doi: 10.1097/01.HP.0000232649.16529.95. Health Phys. 2006. PMID: 17033468 Review.
U.S. Department of Energy (U.S. DOE) regulates its operations with a system of rules, directives, and guidance under the Atomic Energy Act. ...U.S. DOE has recently adopted a management systems approach for general environmental and public protection p …
U.S. Department of Energy (U.S. DOE) regulates its operations with a system of rules, directives, and guidance under the Atomi …
Design of Experiments in metabolomics-related studies: An overview.
Jacyna J, Kordalewska M, Markuszewski MJ. Jacyna J, et al. J Pharm Biomed Anal. 2019 Feb 5;164:598-606. doi: 10.1016/j.jpba.2018.11.027. Epub 2018 Nov 13. J Pharm Biomed Anal. 2019. PMID: 30469109 Review.
Despite such a large increase of interest in this approach recently, its implementation in metabolomics research seems to be limited. Therefore, in this short overview, apart from summarizing some basic concepts of DoE, we wanted to provide a guideline for those who …
Despite such a large increase of interest in this approach recently, its implementation in metabolomics research seems to be limited. …
Evaluation of a DoE based approach for comprehensive modelling of the effect of lipid nanoparticle composition on nucleic acid delivery.
Qin Y, Walters AA, Rouatbi N, Wang JT, Abdel-Bar HM, Al-Jamal KT. Qin Y, et al. Biomaterials. 2023 Aug;299:122158. doi: 10.1016/j.biomaterials.2023.122158. Epub 2023 May 15. Biomaterials. 2023. PMID: 37243988 Free article.
Small interfering RNA (siRNA) and messenger RNA (mRNA) based drugs have been suggested for a wide range of pathologies, and their respective lipid nanoparticle (LNP) formulations have been optimised using a Design of Experiments (DoE) approach. However, it is uncertain as …
Small interfering RNA (siRNA) and messenger RNA (mRNA) based drugs have been suggested for a wide range of pathologies, and their respective …
Design of experiment techniques for the optimization of chromatographic analysis conditions: A review.
Peng L, Gao X, Wang L, Zhu A, Cai X, Li P, Li W. Peng L, et al. Electrophoresis. 2022 Oct;43(18-19):1882-1898. doi: 10.1002/elps.202200072. Epub 2022 Jul 18. Electrophoresis. 2022. PMID: 35848309 Review.
Design of experiment (DoE) techniques have been widely used in the field of chromatographic parameters optimization as a valuable tool. ...Current problems and future outlooks are finally given to provide a certain inspiration of research in the application of Do …
Design of experiment (DoE) techniques have been widely used in the field of chromatographic parameters optimization as a valuable too …
11,287 results
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