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Further Findings Concerning Endothelial Damage in COVID-19 Patients.
Gelzo M, Cacciapuoti S, Pinchera B, De Rosa A, Cernera G, Scialò F, Comegna M, Mormile M, Fabbrocini G, Parrella R, Corso G, Gentile I, Castaldo G. Gelzo M, et al. Biomolecules. 2021 Sep 16;11(9):1368. doi: 10.3390/biom11091368. Biomolecules. 2021. PMID: 34572581 Free PMC article.
Systemic vascular damage with micro/macro-thrombosis is a typical feature of severe COVID-19. However, the pathogenesis of this damage and its predictive biomarkers remain poorly defined. ...The lower MCP-2 levels after 1 week suggest that endothelial damage trigger …
Systemic vascular damage with micro/macro-thrombosis is a typical feature of severe COVID-19. However, the pathogenesis of thi …
Matrix metalloproteinases (MMP) 3 and 9 as biomarkers of severity in COVID-19 patients.
Gelzo M, Cacciapuoti S, Pinchera B, De Rosa A, Cernera G, Scialò F, Comegna M, Mormile M, Fabbrocini G, Parrella R, Corso G, Gentile I, Castaldo G. Gelzo M, et al. Sci Rep. 2022 Jan 24;12(1):1212. doi: 10.1038/s41598-021-04677-8. Sci Rep. 2022. PMID: 35075175 Free PMC article. Clinical Trial.
The molecular basis of the wide clinical heterogeneity of Coronavirus disease 2019 (COVID-19) is still unknown. Matrix metalloproteinases (MMPs) may have a role in the lung damage and regeneration that occur in severe patients. ...In conclusion, serum MMP3 ma …
The molecular basis of the wide clinical heterogeneity of Coronavirus disease 2019 (COVID-19) is still unknown. Matrix …
Cytometric analysis of patients with COVID-19: what is changed in the second wave?
Scalia G, Raia M, Gelzo M, Cacciapuoti S, De Rosa A, Pinchera B, Scotto R, Giaccone A, Mormile M, Fabbrocini G, Gentile I, Parrella R, Castaldo G. Scalia G, et al. J Transl Med. 2021 Sep 23;19(1):403. doi: 10.1186/s12967-021-03072-1. J Transl Med. 2021. PMID: 34556132 Free PMC article.
BACKGROUND: Coronavirus disease 2019 (COVID-19) pandemic had a 1st wave in Europe from March to May 2020 and a 2nd wave since September 2020. ...Herein, we describe the results obtained from COVID-19 patients of the 2nd wave. METHODS: We analyze …
BACKGROUND: Coronavirus disease 2019 (COVID-19) pandemic had a 1st wave in Europe from March to May 2020 and a 2nd wave …
A Transient Increase in the Serum ANCAs in Patients with SARS-CoV-2 Infection: A Signal of Subclinical Vasculitis or an Epiphenomenon with No Clinical Manifestations? A Pilot Study.
Gelzo M, Cacciapuoti S, Pinchera B, De Rosa A, Cernera G, Scialò F, Comegna M, Mormile M, Gallicchio A, Fabbrocini G, Parrella R, Corso G, Gentile I, Castaldo G. Gelzo M, et al. Viruses. 2021 Aug 29;13(9):1718. doi: 10.3390/v13091718. Viruses. 2021. PMID: 34578298 Free PMC article.
A relationship is emerging between SARS-CoV-2 infections and ANCA-associated vasculitis (AAV) because: (i) the pulmonary involvement of COVID-19 may mimic that observed in patients with AAV; (ii) the two diseases may occur together; (iii) COV
A relationship is emerging between SARS-CoV-2 infections and ANCA-associated vasculitis (AAV) because: (i) the pulmonar …
Inducible Nitric Oxide Synthase (iNOS): Why a Different Production in COVID-19 Patients of the Two Waves?
Gelzo M, Scialò F, Cacciapuoti S, Pinchera B, De Rosa A, Cernera G, Comegna M, Tripodi L, Schiano Moriello N, Mormile M, Fabbrocini G, Parrella R, Corso G, Gentile I, Castaldo G. Gelzo M, et al. Viruses. 2022 Mar 5;14(3):534. doi: 10.3390/v14030534. Viruses. 2022. PMID: 35336941 Free PMC article.
Profound clinical differences between the first and second waves of COVID-19 were observed in Europe. Nitric oxide (NO) may positively impact patients with Severe Acute Respiratory Syndrome CoronaVirus-2 (SARS-CoV
Profound clinical differences between the first and second waves of COVID-19 were observed in Europe. Nitric oxide (NO) may po …
SARS-CoV-2 Pandemic Tracing in Italy Highlights Lineages with Mutational Burden in Growing Subsets.
Boccia A, Tufano R, Ferrucci V, Sepe L, Bianchi M, Pascarella S, Zollo M, Paolella G. Boccia A, et al. Int J Mol Sci. 2022 Apr 9;23(8):4155. doi: 10.3390/ijms23084155. Int J Mol Sci. 2022. PMID: 35456974 Free PMC article.
Tracing the appearance and evolution of virus variants is essential in the management of the COVID-19 pandemic. Here, we focus on SARS-CoV-2 spread in Italian patients by using viral sequences deposited in public databases and a tracing procedur …
Tracing the appearance and evolution of virus variants is essential in the management of the COVID-19 pandemic. Here, we focus …
Biomarkers of Endothelial Damage in Distinct Phases of Multisystem Inflammatory Syndrome in Children.
Gelzo M, Giannattasio A, Maglione M, Muzzica S, D'Anna C, Scialò F, Gagliardo T, Grieco M, Tipo V, Castaldo G. Gelzo M, et al. Metabolites. 2022 Jul 24;12(8):680. doi: 10.3390/metabo12080680. Metabolites. 2022. PMID: 35893247 Free PMC article.
Endothelial hyperinflammation and vasculitis are known hallmarks of acute COVID-19 and multisystem inflammatory syndrome in children (MIS-C). ...
Endothelial hyperinflammation and vasculitis are known hallmarks of acute COVID-19 and multisystem inflammatory syndrome in ch …