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Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD.
Mol Cell. 2021 Feb 18;81(4):767-783.e11. doi: 10.1016/j.molcel.2020.12.006. Epub 2020 Dec 16.
Mol Cell. 2021.
PMID: 33333017
Free PMC article.
53BP1-shieldin-dependent DSB processing in BRCA1-deficient cells requires CST-Polα-primase fill-in synthesis.
Mirman Z, Sasi NK, King A, Chapman JR, de Lange T.
Mirman Z, et al.
Nat Cell Biol. 2022 Jan;24(1):51-61. doi: 10.1038/s41556-021-00812-9. Epub 2022 Jan 13.
Nat Cell Biol. 2022.
PMID: 35027730
Free PMC article.
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Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining.
Francica P, Mutlu M, Blomen VA, Oliveira C, Nowicka Z, Trenner A, Gerhards NM, Bouwman P, Stickel E, Hekkelman ML, Lingg L, Klebic I, van de Ven M, de Korte-Grimmerink R, Howald D, Jonkers J, Sartori AA, Fendler W, Chapman JR, Brummelkamp T, Rottenberg S.
Francica P, et al.
Cell Rep. 2020 Aug 25;32(8):108068. doi: 10.1016/j.celrep.2020.108068.
Cell Rep. 2020.
PMID: 32846126
Free article.
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53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms.
Cuella-Martin R, Oliveira C, Lockstone HE, Snellenberg S, Grolmusova N, Chapman JR.
Cuella-Martin R, et al.
Mol Cell. 2016 Oct 6;64(1):51-64. doi: 10.1016/j.molcel.2016.08.002. Epub 2016 Aug 18.
Mol Cell. 2016.
PMID: 27546791
Free PMC article.
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The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.
Barazas M, Annunziato S, Pettitt SJ, de Krijger I, Ghezraoui H, Roobol SJ, Lutz C, Frankum J, Song FF, Brough R, Evers B, Gogola E, Bhin J, van de Ven M, van Gent DC, Jacobs JJL, Chapman R, Lord CJ, Jonkers J, Rottenberg S.
Barazas M, et al.
Cell Rep. 2018 May 15;23(7):2107-2118. doi: 10.1016/j.celrep.2018.04.046.
Cell Rep. 2018.
PMID: 29768208
Free PMC article.
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A map of human PRDM9 binding provides evidence for novel behaviors of PRDM9 and other zinc-finger proteins in meiosis.
Altemose N, Noor N, Bitoun E, Tumian A, Imbeault M, Chapman JR, Aricescu AR, Myers SR.
Altemose N, et al.
Elife. 2017 Oct 26;6:e28383. doi: 10.7554/eLife.28383.
Elife. 2017.
PMID: 29072575
Free PMC article.
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