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Recent progress in the metabolic engineering of alkaloids in plant systems.
Curr Opin Biotechnol. 2013 Apr;24(2):354-65. doi: 10.1016/j.copbio.2012.08.003. Epub 2012 Sep 3.
Curr Opin Biotechnol. 2013.
PMID: 22954587
Free PMC article.
Review.
Redesign of a dioxygenase in morphine biosynthesis.
Runguphan W, Glenn WS, O'Connor SE.
Runguphan W, et al.
Chem Biol. 2012 Jun 22;19(6):674-8. doi: 10.1016/j.chembiol.2012.04.017.
Chem Biol. 2012.
PMID: 22726681
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Structural determinants of reductive terpene cyclization in iridoid biosynthesis.
Kries H, Caputi L, Stevenson CEM, Kamileen MO, Sherden NH, Geu-Flores F, Lawson DM, O'Connor SE.
Kries H, et al.
Nat Chem Biol. 2016 Jan;12(1):6-8. doi: 10.1038/nchembio.1955. Epub 2015 Nov 9.
Nat Chem Biol. 2016.
PMID: 26551396
Free PMC article.
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Iridoid synthase activity is common among the plant progesterone 5β-reductase family.
Munkert J, Pollier J, Miettinen K, Van Moerkercke A, Payne R, Müller-Uri F, Burlat V, O'Connor SE, Memelink J, Kreis W, Goossens A.
Munkert J, et al.
Mol Plant. 2015 Jan;8(1):136-52. doi: 10.1016/j.molp.2014.11.005. Epub 2014 Dec 11.
Mol Plant. 2015.
PMID: 25578278
Free article.
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Gene Discovery in Gelsemium Highlights Conserved Gene Clusters in Monoterpene Indole Alkaloid Biosynthesis.
Franke J, Kim J, Hamilton JP, Zhao D, Pham GM, Wiegert-Rininger K, Crisovan E, Newton L, Vaillancourt B, Tatsis E, Buell CR, O'Connor SE.
Franke J, et al.
Chembiochem. 2019 Jan 2;20(1):83-87. doi: 10.1002/cbic.201800592. Epub 2018 Nov 13.
Chembiochem. 2019.
PMID: 30300974
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An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis.
Geu-Flores F, Sherden NH, Courdavault V, Burlat V, Glenn WS, Wu C, Nims E, Cui Y, O'Connor SE.
Geu-Flores F, et al.
Nature. 2012 Dec 6;492(7427):138-42. doi: 10.1038/nature11692. Epub 2012 Nov 21.
Nature. 2012.
PMID: 23172143
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The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus.
Van Moerkercke A, Steensma P, Schweizer F, Pollier J, Gariboldi I, Payne R, Vanden Bossche R, Miettinen K, Espoz J, Purnama PC, Kellner F, Seppänen-Laakso T, O'Connor SE, Rischer H, Memelink J, Goossens A.
Van Moerkercke A, et al.
Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8130-5. doi: 10.1073/pnas.1504951112. Epub 2015 Jun 15.
Proc Natl Acad Sci U S A. 2015.
PMID: 26080427
Free PMC article.
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