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A surprising range of modified-methionyl S-adenosylmethionine analogues support bacterial growth.
Microbiology (Reading). 2015 Mar;161(Pt 3):674-82. doi: 10.1099/mic.0.000034.
Microbiology (Reading). 2015.
PMID: 25717169
Free PMC article.
Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.
Ohren J, Parungao GG, Viola RE.
Ohren J, et al.
Acta Crystallogr F Struct Biol Commun. 2019 Apr 1;75(Pt 4):290-298. doi: 10.1107/S2053230X19002772. Epub 2019 Apr 2.
Acta Crystallogr F Struct Biol Commun. 2019.
PMID: 30950830
Free PMC article.
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Alternative substrates selective for S-adenosylmethionine synthetases from pathogenic bacteria.
Zano SP, Bhansali P, Luniwal A, Viola RE.
Zano SP, et al.
Arch Biochem Biophys. 2013 Aug 1;536(1):64-71. doi: 10.1016/j.abb.2013.05.008. Epub 2013 May 24.
Arch Biochem Biophys. 2013.
PMID: 23711747
Free PMC article.
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Producing proficient methyl donors from alternative substrates of S-adenosylmethionine synthetase.
Wijayasinghe YS, Blumenthal RM, Viola RE.
Wijayasinghe YS, et al.
Biochemistry. 2014 Mar 11;53(9):1521-6. doi: 10.1021/bi401556p. Epub 2014 Feb 21.
Biochemistry. 2014.
PMID: 24528526
Free PMC article.
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Complementation of a metK-deficient E. coli strain with heterologous AdoMet synthetase genes.
Parungao GG, Zhao M, Wang Q, Zano SP, Viola RE, Blumenthal RM.
Parungao GG, et al.
Microbiology (Reading). 2017 Dec;163(12):1812-1821. doi: 10.1099/mic.0.000565. Epub 2017 Nov 7.
Microbiology (Reading). 2017.
PMID: 29111970
Free PMC article.
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