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Page 1
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, Baker AM, Roy-Luzarraga M, Graham TA, Foster J, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Balkwill FR, Sosabowski J, Cutillas PR, Frezza C, Sancho P, Hodivala-Dilke K. Demircioglu F, et al. Nat Commun. 2020 Mar 10;11(1):1290. doi: 10.1038/s41467-020-15104-3. Nat Commun. 2020. PMID: 32157087 Free PMC article.
Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells.
Wong PP, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O, Meng YM, Meng Q, Bodrug N, Dukinfield MS, Reynolds LE, Elia G, Clear A, Harwood C, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Matchett KP, Henderson NC, Szlosarek PW, Dreger SA, Smith S, Jones JL, Gribben JG, Cutillas PR, Meier P, Sanz-Moreno V, Hodivala-Dilke KM. Wong PP, et al. Cell. 2020 Jun 11;181(6):1346-1363.e21. doi: 10.1016/j.cell.2020.02.003. Epub 2020 May 29. Cell. 2020. PMID: 32473126 Free article.
Dual role of pericyte α6β1-integrin in tumour blood vessels.
Reynolds LE, D'Amico G, Lechertier T, Papachristodoulou A, Muñoz-Félix JM, De Arcangelis A, Baker M, Serrels B, Hodivala-Dilke KM. Reynolds LE, et al. J Cell Sci. 2017 May 1;130(9):1583-1595. doi: 10.1242/jcs.197848. Epub 2017 Mar 13. J Cell Sci. 2017. PMID: 28289267 Free PMC article.
ERG activity is regulated by endothelial FAK coupling with TRIM25/USP9x in vascular patterning.
D'Amico G, Fernandez I, Gómez-Escudero J, Kim H, Maniati E, Azman MS, Mardakheh FK, Serrels B, Serrels A, Parsons M, Squire A, Birdsey GM, Randi AM, Bolado-Carrancio A, Gangeswaran R, Reynolds LE, Bodrug N, Wang Y, Wang J, Meier P, Hodivala-Dilke KM. D'Amico G, et al. Development. 2022 Jul 1;149(13):dev200528. doi: 10.1242/dev.200528. Epub 2022 Jul 12. Development. 2022. PMID: 35723257 Free PMC article.
Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease.
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J, Bedi KC Jr, Margulies KB, Sanz-Moreno V, Hobbs A, Hodivala-Dilke K. Dukinfield M, et al. J Pathol. 2019 Dec;249(4):523-535. doi: 10.1002/path.5340. Epub 2019 Oct 30. J Pathol. 2019. PMID: 31424556 Free PMC article.
Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3.
Weinmüller M, Rechenmacher F, Kiran Marelli U, Reichart F, Kapp TG, Räder AFB, Di Leva FS, Marinelli L, Novellino E, Muñoz-Félix JM, Hodivala-Dilke K, Schumacher A, Fanous J, Gilon C, Hoffman A, Kessler H. Weinmüller M, et al. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16405-16409. doi: 10.1002/anie.201709709. Epub 2017 Nov 23. Angew Chem Int Ed Engl. 2017. PMID: 29072809
Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861.
Pedrosa AR, Bodrug N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T, Hodivala-Dilke KM. Pedrosa AR, et al. Cancer Res. 2019 Sep 1;79(17):4371-4386. doi: 10.1158/0008-5472.CAN-18-3934. Epub 2019 Jun 12. Cancer Res. 2019. PMID: 31189647