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Second generation steroidal 4-aminoquinolines are potent, dual-target inhibitors of the botulinum neurotoxin serotype A metalloprotease and P. falciparum malaria.
J Med Chem. 2014 May 22;57(10):4134-53. doi: 10.1021/jm500033r. Epub 2014 May 1.
J Med Chem. 2014.
PMID: 24742203
Free PMC article.
The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.
Opsenica I, Filipovic V, Nuss JE, Gomba LM, Opsenica D, Burnett JC, Gussio R, Solaja BA, Bavari S.
Opsenica I, et al.
Eur J Med Chem. 2012 Jul;53:374-9. doi: 10.1016/j.ejmech.2012.03.043. Epub 2012 Mar 30.
Eur J Med Chem. 2012.
PMID: 22516424
Free PMC article.
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