This study provides a new perspective on the relationship between age-related DNA methylation and insulin function. The hexokinase-1 (HK1)'s methylation level in the whole blood can be considered as a potential biomarker for the risk of diabetes in healthy individuals.
Keywords: DNA methylation; age; insulin resistance; insulin secretion.
© 2020 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.