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Activation of GABA(A) receptors inhibits T cell proliferation.
Sparrow EL, James S, Hussain K, Beers SA, Cragg MS, Bogdanov YD. Sparrow EL, et al. PLoS One. 2021 May 20;16(5):e0251632. doi: 10.1371/journal.pone.0251632. eCollection 2021. PLoS One. 2021. PMID: 34014994 Free PMC article.
Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect.
Bavo F, de-Jong H, Petersen J, Falk-Petersen CB, Löffler R, Sparrow E, Rostrup F, Eliasen JN, Wilhelmsen KS, Barslund K, Bundgaard C, Nielsen B, Kristiansen U, Wellendorph P, Bogdanov Y, Frølund B. Bavo F, et al. J Med Chem. 2021 Dec 23;64(24):17795-17812. doi: 10.1021/acs.jmedchem.1c00290. Epub 2021 Dec 15. J Med Chem. 2021. PMID: 34908407