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7-Chloro-4-(Phenylselanyl) Quinoline Is a Novel Multitarget Therapy to Combat Peripheral Neuropathy and Comorbidities Induced by Paclitaxel in Mice.
Paltian JJ, Dos Reis AS, Martins AWS, Blödorn EB, Dellagostin EN, Soares LK, Schumacher RF, Campos VF, Alves D, Luchese C, Wilhelm EA. Paltian JJ, et al. Mol Neurobiol. 2022 Oct;59(10):6567-6589. doi: 10.1007/s12035-022-02991-4. Epub 2022 Aug 15. Mol Neurobiol. 2022. PMID: 35965270
Likewise, 4-PSQ reduced both anxious behavior and cognitive impairment in mice with PIPN. We believe that effects of 4-PSQ may be associated, at least in part, with the modulation of oxidative stress, reduction of neuroinflammation, and normalizing Ca(2+)ATPase activity in …
Likewise, 4-PSQ reduced both anxious behavior and cognitive impairment in mice with PIPN. We believe that effects of 4-PSQ may be ass …
The Antinociceptive Responses of MTDZ to Paclitaxel-Induced Peripheral Neuropathy and Acute Nociception in Mice: Behavioral, Pharmacological, and Biochemical Approaches.
da Motta KP, Martins CC, Macedo VM, Dos Santos BF, Domingues NLC, Luchese C, Wilhelm EA. da Motta KP, et al. Pharmaceuticals (Basel). 2023 Aug 29;16(9):1217. doi: 10.3390/ph16091217. Pharmaceuticals (Basel). 2023. PMID: 37765025 Free PMC article.
The efficacy of 5-((4-methoxyphenyl)thio)benzo[c][1,2,5] thiodiazole (MTDZ) in mitigating paclitaxel (PTX)-induced peripheral neuropathy was investigated in male and female Swiss mice. The study examined the effects of MTDZ on various pathways, including transient receptor …
The efficacy of 5-((4-methoxyphenyl)thio)benzo[c][1,2,5] thiodiazole (MTDZ) in mitigating paclitaxel (PTX)-induced peripheral neuropathy was …
4-(Phenylselanyl)-2H-chromen-2-one-Loaded Nanocapsule Suspension-A Promising Breakthrough in Pain Management: Comprehensive Molecular Docking, Formulation Design, and Toxicological and Pharmacological Assessments in Mice.
da Fonseca CAR, Prado VC, Paltian JJ, Kazmierczak JC, Schumacher RF, Sari MHM, Cordeiro LM, da Silva AF, Soares FAA, Oliboni RDS, Luchese C, Cruz L, Wilhelm EA. da Fonseca CAR, et al. Pharmaceutics. 2024 Feb 14;16(2):269. doi: 10.3390/pharmaceutics16020269. Pharmaceutics. 2024. PMID: 38399323 Free PMC article.
Therapies for the treatment of pain and inflammation continue to pose a global challenge, emphasizing the significant impact of pain on patients' quality of life. Therefore, this study aimed to investigate the effects of 4-(Phenylselanyl)-2H-chromen-2-one (4-PSCO) on pain- …
Therapies for the treatment of pain and inflammation continue to pose a global challenge, emphasizing the significant impact of pain on pati …