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N-(3-((3-(trifluoromethyl)phenyl)selanyl)prop-2-yn-1-yl) benzamide induces antidepressant-like effect in mice: involvement of the serotonergic system.
Pires CS, da Rocha MJ, Presa MH, Zuge NP, Kuntz NEB, Godoi B, Bortolatto CF, Brüning CA. Pires CS, et al. Psychopharmacology (Berl). 2024 Apr 18. doi: 10.1007/s00213-024-06588-8. Online ahead of print. Psychopharmacology (Berl). 2024. PMID: 38635075
While the exact causes of MDD are not fully understood, the deficit of monoamines, especially serotonin and noradrenaline, is widely accepted. Resistance to long-term treatments and adverse effects are often observed, highlighting the need for new pharmacological therapies …
While the exact causes of MDD are not fully understood, the deficit of monoamines, especially serotonin and noradrenaline, is widely accepte …
Pharmacological evidence for glutamatergic pathway involvement in the antidepressant-like effects of 2-phenyl-3-(phenylselanyl)benzofuran in male Swiss mice.
Rech TDST, Strelow DN, Krüger LD, Neto JSS, Blödorn GB, Alves D, Brüning CA, Bortolatto CF. Rech TDST, et al. Naunyn Schmiedebergs Arch Pharmacol. 2023 Nov;396(11):3033-3044. doi: 10.1007/s00210-023-02508-3. Epub 2023 May 9. Naunyn Schmiedebergs Arch Pharmacol. 2023. PMID: 37160481
The pretreatment of mice with N-methyl-D-aspartate (NMDA) (0.1 pmol/site, intracerebroventricular, icv, a selective agonist of the NMDA receptors), D-serine (30 g/site, icv, a co-agonist at the NMDA receptor), arcaine (1 mg/kg, intraperitoneal, ip, an antagonist of the polyamine- …
The pretreatment of mice with N-methyl-D-aspartate (NMDA) (0.1 pmol/site, intracerebroventricular, icv, a selective agonist of the NMDA rece …