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The application of adenine deaminase in antibody affinity maturation.
Qu B, Zhao Y, An L, Hang H. Qu B, et al. Appl Microbiol Biotechnol. 2023 Apr;107(7-8):2661-2670. doi: 10.1007/s00253-022-12324-z. Epub 2023 Mar 16. Appl Microbiol Biotechnol. 2023. PMID: 36929186
Examples presented in this study showed that ADA contributed to the improvement of antibody affinity either with or without AID in CHO display. KEY POINTS: ADA is able to induce random mutations on antibody gene in mammalian cells. ...
Examples presented in this study showed that ADA contributed to the improvement of antibody affinity either with or without AID in CHO displ …