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LRP5 regulates cardiomyocyte proliferation and neonatal heart regeneration by the AKT/P21 pathway.
Zhou H, Zhang F, Wu Y, Liu H, Duan R, Liu Y, Wang Y, He X, Zhang Y, Ma X, Guan Y, Liu Y, Liang D, Zhou L, Chen YH. Zhou H, et al. J Cell Mol Med. 2022 May;26(10):2981-2994. doi: 10.1111/jcmm.17311. Epub 2022 Apr 16. J Cell Mol Med. 2022. PMID: 35429093 Free PMC article.
The neonatal heart can efficiently regenerate within a short period after birth, whereas the adult mammalian heart has extremely limited capacity to regenerate. The molecular mechanisms underlying neonatal heart regeneration remain elusive. Here, we revealed …
The neonatal heart can efficiently regenerate within a short period after birth, whereas the adult mammalian heart has extreme …
HAND factors regulate cardiac lineage commitment and differentiation from human pluripotent stem cells.
Guo H, Hang C, Lin B, Lin Z, Xiong H, Zhang M, Lu R, Liu J, Shi D, Xie D, Liu Y, Liang D, Yang J, Chen YH. Guo H, et al. Stem Cell Res Ther. 2024 Feb 5;15(1):31. doi: 10.1186/s13287-024-03649-9. Stem Cell Res Ther. 2024. PMID: 38317221 Free PMC article.
RESULTS: Either HAND1 or HAND2 knockout did not affect the cardiomyocyte differentiation kinetics, whereas depletion of HAND1/2 resulted in delayed differentiation onset. HAND1 knockout biased cardiac mesoderm toward second heart field progenitors at the expense of first …
RESULTS: Either HAND1 or HAND2 knockout did not affect the cardiomyocyte differentiation kinetics, whereas depletion of HAND1/2 resulted in …