Abstract
Very virulent infectious bursal disease virus (vvIBDV) causes high mortality in chickens but measures to reduce the mortality have not been explored. Chickens (8-9 weeks) were treated with 3 agents before and during vvIBDV inoculation. Dexamethasone treatment reduced the mortality of infected chickens (40.7% vs. 3.7%; p < 0.001), but treatment with aspirin or vitamin E plus selenium did not affect the mortality. The bursa of Fabricius appeared to have shrunk in both dead and surviving chickens (p < 0.01). The results indicate that dexamethasone can reduce mortality in vvIBDV-infected chickens and may provide therapeutic clues for saving individual birds infected by the virus.
Keywords:
Very virulent infectious bursal disease virus; aspirin; bursa of Fabricius; bursa-to-body-weight ratio; nitric oxide; selenium; vitamin E.
© 2021 The Korean Society of Veterinary Science.
MeSH terms
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Animals
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Antioxidants / administration & dosage
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Antioxidants / pharmacology
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Aspirin / administration & dosage
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Aspirin / pharmacology
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Birnaviridae Infections / mortality
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Birnaviridae Infections / prevention & control
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Birnaviridae Infections / veterinary*
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Chickens*
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Dexamethasone / pharmacology*
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Immunosuppressive Agents / administration & dosage
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Immunosuppressive Agents / pharmacology*
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Infectious bursal disease virus / physiology
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Poultry Diseases / mortality
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Poultry Diseases / prevention & control*
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Selenium / administration & dosage
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Selenium / pharmacology
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Vitamin E / administration & dosage
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Vitamin E / pharmacology
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Vitamins / administration & dosage
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Vitamins / pharmacology
Substances
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Anti-Inflammatory Agents
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Anti-Inflammatory Agents, Non-Steroidal
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Antioxidants
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Immunosuppressive Agents
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Vitamins
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Vitamin E
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Dexamethasone
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Selenium
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Aspirin