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Synthesis by diastereomeric resolution, biochemical evaluation and molecular modelling of chiral 3-hydroxyl b-lactam microtubule-targeting agents for the treatment of triple negative breast and chemoresistant colorectal cancers.
Bioorg Chem. 2023 Dec;141:106877. doi: 10.1016/j.bioorg.2023.106877. Epub 2023 Sep 30.
Bioorg Chem. 2023.
PMID: 37804699
Free article.
Application of 2D EXSY and qNMR Spectroscopy for Diastereomeric Excess Determination Following Chiral Resolution of β-Lactams.
McLoughlin EC, O'Brien JE, Trujillo C, Meegan MJ, O'Boyle NM.
McLoughlin EC, et al.
ChemistryOpen. 2023 Jun;12(6):e202200119. doi: 10.1002/open.202200119. Epub 2022 Jul 25.
ChemistryOpen. 2023.
PMID: 35876400
Free PMC article.
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