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Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin.
J Biol Chem. 2021 Oct;297(4):101177. doi: 10.1016/j.jbc.2021.101177. Epub 2021 Sep 8.
J Biol Chem. 2021.
PMID: 34508778
Free PMC article.
The loss-of-function PCSK9Q152H variant increases ER chaperones GRP78 and GRP94 and protects against liver injury.
Lebeau PF, Wassef H, Byun JH, Platko K, Ason B, Jackson S, Dobroff J, Shetterly S, Richards WG, Al-Hashimi AA, Won KD, Mbikay M, Prat A, Tang A, Paré G, Pasqualini R, Seidah NG, Arap W, Chrétien M, Austin RC.
Lebeau PF, et al.
J Clin Invest. 2021 Jan 19;131(2):e128650. doi: 10.1172/JCI128650.
J Clin Invest. 2021.
PMID: 33211673
Free PMC article.
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