To date, dozens of stress-induced cellular senescence phenotypes have been reported. These cellular senescence states may differ substantially from each other, as well as from replicative senescence through the presence of specific senescence features. Here, we attempted to catalog virtually all of the cellular senescence-like states that can be induced by low molecular weight compounds. We summarized biological markers, molecular pathways involved in senescence establishment, and specific traits of cellular senescence states induced by more than fifty small molecule compounds.
Keywords: DNA damage; DNA replication stress; aging; cell stress; cellular senescence; epigenetic modifiers.
© 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.