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Stepwise pathogenic evolution of Mycobacterium abscessus.
Bryant JM, Brown KP, Burbaud S, Everall I, Belardinelli JM, Rodriguez-Rincon D, Grogono DM, Peterson CM, Verma D, Evans IE, Ruis C, Weimann A, Arora D, Malhotra S, Bannerman B, Passemar C, Templeton K, MacGregor G, Jiwa K, Fisher AJ, Blundell TL, Ordway DJ, Jackson M, Parkhill J, Floto RA. Bryant JM, et al. Science. 2021 Apr 30;372(6541):eabb8699. doi: 10.1126/science.abb8699. Science. 2021. PMID: 33926925 Free PMC article.
Mycobacterium abscessus pathogenesis identified by phenogenomic analyses.
Boeck L, Burbaud S, Skwark M, Pearson WH, Sangen J, Wuest AW, Marshall EKP, Weimann A, Everall I, Bryant JM, Malhotra S, Bannerman BP, Kierdorf K, Blundell TL, Dionne MS, Parkhill J, Andres Floto R. Boeck L, et al. Nat Microbiol. 2022 Sep;7(9):1431-1441. doi: 10.1038/s41564-022-01204-x. Epub 2022 Aug 25. Nat Microbiol. 2022. PMID: 36008617 Free PMC article.
Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach.
Charoensutthivarakul S, Thomas SE, Curran A, Brown KP, Belardinelli JM, Whitehouse AJ, Acebrón-García-de-Eulate M, Sangan J, Gramani SG, Jackson M, Mendes V, Floto RA, Blundell TL, Coyne AG, Abell C. Charoensutthivarakul S, et al. ACS Infect Dis. 2022 Feb 11;8(2):296-309. doi: 10.1021/acsinfecdis.1c00432. Epub 2022 Jan 17. ACS Infect Dis. 2022. PMID: 35037462 Free PMC article.
Discovery of Novel Inhibitors of Uridine Diphosphate-N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients.
Acebrón-García-de-Eulate M, Mayol-Llinàs J, Holland MTO, Kim SY, Brown KP, Marchetti C, Hess J, Di Pietro O, Mendes V, Abell C, Floto RA, Coyne AG, Blundell TL. Acebrón-García-de-Eulate M, et al. J Med Chem. 2022 Feb 10;65(3):2149-2173. doi: 10.1021/acs.jmedchem.1c01684. Epub 2022 Jan 26. J Med Chem. 2022. PMID: 35080396 Free PMC article.