Lipofuscin Granule Bisretinoid Oxidation in the Human Retinal Pigment Epithelium forms Cytotoxic Carbonyls.
Yakovleva M, Dontsov A, Trofimova N, Sakina N, Kononikhin A, Aybush A, Gulin A, Feldman T, Ostrovsky M.
Yakovleva M, et al.
Int J Mol Sci. 2021 Dec 25;23(1):222. doi: 10.3390/ijms23010222.
Int J Mol Sci. 2021.
PMID: 35008647
Free PMC article.
In the presence of oxygen, bisretinoids are also oxidized, forming various products, consisting primarily of aldehydes and ketones, which are also potentially cytotoxic. In a prior study, we identified that in AMD, bisretinoid oxidation products are increased in RPE lipofu …
In the presence of oxygen, bisretinoids are also oxidized, forming various products, consisting primarily of aldehydes and ketones, which ar …