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Patient-Specific iPSCs-Based Models of Neurodegenerative Diseases: Focus on Aberrant Calcium Signaling.
Grekhnev DA, Kaznacheyeva EV, Vigont VA. Grekhnev DA, et al. Int J Mol Sci. 2022 Jan 6;23(2):624. doi: 10.3390/ijms23020624. Int J Mol Sci. 2022. PMID: 35054808 Free PMC article. Review.
The use of the cells most vulnerable to a particular pathology makes it possible to identify specific pathological mechanisms and greatly facilitates the task of selecting the most effective drugs. ...
The use of the cells most vulnerable to a particular pathology makes it possible to identify specific pathological mechanisms and gre …
Protein Interactome of Amyloid-β as a Therapeutic Target.
Lazarev VF, Dutysheva EA, Kanunikov IE, Guzhova IV, Margulis BA. Lazarev VF, et al. Pharmaceuticals (Basel). 2023 Feb 16;16(2):312. doi: 10.3390/ph16020312. Pharmaceuticals (Basel). 2023. PMID: 37259455 Free PMC article. Review.
Understanding the Mechanism of Light-Induced Age-Related Decrease in Melanin Concentration in Retinal Pigment Epithelium Cells.
Dontsov AE, Yakovleva MA, Vasin AA, Gulin AA, Aybush AV, Nadtochenko VA, Ostrovsky MA. Dontsov AE, et al. Int J Mol Sci. 2023 Aug 23;24(17):13099. doi: 10.3390/ijms241713099. Int J Mol Sci. 2023. PMID: 37685907 Free PMC article.
The formation of these products occurs as a result of the oxidative degradation of melanin by superoxide radicals, which are generated by the lipofuscin part of the melanolipofuscin granule. We identified these products both in the composition of melanolipofuscin granules …
The formation of these products occurs as a result of the oxidative degradation of melanin by superoxide radicals, which are generated by th …
Lipofuscin Granule Bisretinoid Oxidation in the Human Retinal Pigment Epithelium forms Cytotoxic Carbonyls.
Yakovleva M, Dontsov A, Trofimova N, Sakina N, Kononikhin A, Aybush A, Gulin A, Feldman T, Ostrovsky M. Yakovleva M, et al. Int J Mol Sci. 2021 Dec 25;23(1):222. doi: 10.3390/ijms23010222. Int J Mol Sci. 2021. PMID: 35008647 Free PMC article.
In the presence of oxygen, bisretinoids are also oxidized, forming various products, consisting primarily of aldehydes and ketones, which are also potentially cytotoxic. In a prior study, we identified that in AMD, bisretinoid oxidation products are increased in RPE lipofu …
In the presence of oxygen, bisretinoids are also oxidized, forming various products, consisting primarily of aldehydes and ketones, which ar …