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The α2AR/Caveolin-1/p38MAPK/NF-κB axis explains dexmedetomidine protection against lung injury following intestinal ischaemia-reperfusion.
Xu L, Li T, Chen Q, Liu Z, Chen Y, Hu K, Zhang X. Xu L, et al. J Cell Mol Med. 2021 Jun 10;25(13):6361-72. doi: 10.1111/jcmm.16614. Online ahead of print. J Cell Mol Med. 2021. PMID: 34114328 Free PMC article.
Intestinal ischaemia-reperfusion (I/R) injury can result in acute lung injury due to ischaemia and hypoxia. ...This study aimed to investigate the role and mechanism of Dex in lung injury caused by intestinal I/R. After establishing a rat model of intestinal I/R …
Intestinal ischaemia-reperfusion (I/R) injury can result in acute lung injury due to ischaemia and hypoxia. ...This study aimed to in …
JAK2/STAT3 inhibition attenuates intestinal ischemia-reperfusion injury via promoting autophagy: in vitro and in vivo study.
Liu Z, Hu K, Chen YS, Huang YJ, Hu Q, Zeng W, Cao Y, Xiao Q, Zhang XK. Liu Z, et al. Mol Biol Rep. 2022 Apr;49(4):2857-2867. doi: 10.1007/s11033-021-07099-x. Epub 2022 Jan 24. Mol Biol Rep. 2022. PMID: 35067814
CONCLUSIONS: JAK2/STAT3 signaling suppresses autophagy process during intestinal I/R, while inhibiting JAK-STAT can be protective against intestinal I/R injury by activating autophagy. These findings expand our knowledge on intestinal I/R injury and provide t …
CONCLUSIONS: JAK2/STAT3 signaling suppresses autophagy process during intestinal I/R, while inhibiting JAK-STAT can be protective aga …