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Identification of Novel Cyanopyridones and Pyrido[2,3-D]Pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies.
Al-Warhi T, Sallam AM, Hemeda LR, El Hassab MA, Aljaeed N, Alotaibi OJ, Doghish AS, Noshy M, Eldehna WM, Ibrahim MH. Al-Warhi T, et al. Pharmaceuticals (Basel). 2022 Oct 13;15(10):1262. doi: 10.3390/ph15101262. Pharmaceuticals (Basel). 2022. PMID: 36297374 Free PMC article.
In the current work, we designed and synthesized three families of non-fused and fused compounds based on cyanopyridone: derivatives of 6-amino-1,2-dihydropyridine-3,5-dicarbonitrile (5a-f) and 3,4,7,8-tetrahydro pyrimidine-6-carbonitrile (6a-b and 7a-e). ...The best antip …
In the current work, we designed and synthesized three families of non-fused and fused compounds based on cyanopyridone: derivatives of 6-am …
1-Benzyl-5-bromo-3-hydrazonoindolin-2-ones as Novel Anticancer Agents: Synthesis, Biological Evaluation and Molecular Modeling Insights.
Al-Warhi T, Almahli H, Maklad RM, Elsayed ZM, El Hassab MA, Alotaibi OJ, Aljaeed N, Ayyad RR, Ghabour HA, Eldehna WM, El-Ashrey MK. Al-Warhi T, et al. Molecules. 2023 Apr 4;28(7):3203. doi: 10.3390/molecules28073203. Molecules. 2023. PMID: 37049966 Free PMC article.
The 4-arylthiazole-bearing derivatives 7c and 7d revealed the best anticancer activity toward MCF-7 cells (IC(50) = 7.17 0.94 and 2.93 0.47, respectively). Furthermore, the VEGFR-2 inhibitory activity for 7c and 7d was evaluated. ...Additionally, the impacts of 7d o …
The 4-arylthiazole-bearing derivatives 7c and 7d revealed the best anticancer activity toward MCF-7 cells (IC(50) = 7.17 0.94 and 2.9 …