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Structure-activity relationship and mechanism of flavonoids on the inhibitory activity of P-glycoprotein (P-gp)-mediated transport of rhodamine123 and daunorubicin in P-gp overexpressed human mouth epidermal carcinoma (KB/MDR) cells.
Fang Y, Liang F, Xia M, Cao W, Pan S, Wu T, Xu X. Fang Y, et al. Among authors: pan s. Food Chem Toxicol. 2021 Sep;155:112381. doi: 10.1016/j.fct.2021.112381. Epub 2021 Jul 1. Food Chem Toxicol. 2021. PMID: 34217736
The inhibition mechanism of selected flavonoids was further investigated by measuring the ATPase activity and expression level of P-gp. Twelve flavonoids improved the uptake of Rho (Rho(F)) and nineteen flavonoids increased the uptake of DNR (DNR(F)) in KB/MDR cells …
The inhibition mechanism of selected flavonoids was further investigated by measuring the ATPase activity and expression level of P-gp. Twel …