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1994 1
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2009 2
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2013 5
2014 2
2015 3
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46 results

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Page 1
Apolipoprotein B, Residual Cardiovascular Risk After Acute Coronary Syndrome, and Effects of Alirocumab.
Hagström E, Steg PG, Szarek M, Bhatt DL, Bittner VA, Danchin N, Diaz R, Goodman SG, Harrington RA, Jukema JW, Liberopoulos E, Marx N, McGinniss J, Manvelian G, Pordy R, Scemama M, White HD, Zeiher AM, Schwartz GG; ODYSSEY OUTCOMES Investigators. Hagström E, et al. Circulation. 2022 Aug 30;146(9):657-672. doi: 10.1161/CIRCULATIONAHA.121.057807. Epub 2022 Jun 30. Circulation. 2022. PMID: 35770629 Free PMC article. Clinical Trial.
METHODS: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary …
METHODS: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab …
Joint pain.
Schaible HG, Richter F, Ebersberger A, Boettger MK, Vanegas H, Natura G, Vazquez E, Segond von Banchet G. Schaible HG, et al. Among authors: vazquez e. Exp Brain Res. 2009 Jun;196(1):153-62. doi: 10.1007/s00221-009-1782-9. Epub 2009 Apr 11. Exp Brain Res. 2009. PMID: 19363606 Review.
Both inflammatory and degenerative diseases of joints are major causes of chronic pain. This overview addresses the clinical problem of joint pain, the nociceptive system of the joint, the mechanisms of peripheral and central sensitization during joint inflammation and lon …
Both inflammatory and degenerative diseases of joints are major causes of chronic pain. This overview addresses the clinical problem …
Building a Beneficial Microbiome from Birth.
Castanys-Muñoz E, Martin MJ, Vazquez E. Castanys-Muñoz E, et al. Among authors: vazquez e. Adv Nutr. 2016 Mar 15;7(2):323-30. doi: 10.3945/an.115.010694. Print 2016 Mar. Adv Nutr. 2016. PMID: 26980815 Free PMC article. Review.
Breast milk and milk glycans in particular are thought to play a major role in shaping the early-life microbiota and promoting its development, thus affecting health. ...
Breast milk and milk glycans in particular are thought to play a major role in shaping the early-life microbiota and promoting its de …
Dynamic chromatin accessibility licenses STAT5- and STAT6-dependent innate-like function of TH9 cells to promote allergic inflammation.
Son A, Meylan F, Gomez-Rodriguez J, Kaul Z, Sylvester M, Falduto GH, Vazquez E, Haque T, Kitakule MM, Wang C, Manthiram K, Qi CF, Cheng J, Gurram RK, Zhu J, Schwartzberg P, Milner JD, Frischmeyer-Guerrerio PA, Schwartz DM. Son A, et al. Among authors: vazquez e. Nat Immunol. 2023 Jun;24(6):1036-1048. doi: 10.1038/s41590-023-01501-5. Epub 2023 Apr 27. Nat Immunol. 2023. PMID: 37106040 Free PMC article.
Allergic diseases are a major global health issue. Interleukin (IL)-9-producing helper T (T(H)9) cells promote allergic inflammation, yet T(H)9 cell effector functions are incompletely understood because their lineage instability makes them challenging to study. ...
Allergic diseases are a major global health issue. Interleukin (IL)-9-producing helper T (T(H)9) cells promote allergic inflammation, …
Current practice in the management of ocular toxoplasmosis.
Yogeswaran K, Furtado JM, Bodaghi B, Matthews JM; International Ocular Toxoplasmosis Study Group; Smith JR. Yogeswaran K, et al. Br J Ophthalmol. 2023 Jul;107(7):973-979. doi: 10.1136/bjophthalmol-2022-321091. Epub 2022 Feb 23. Br J Ophthalmol. 2023. PMID: 35197262
Corticosteroid drugs were administered systemically by 97.4%; 24.7% also injected corticosteroid intravitreally, almost always in combination with an antimicrobial drug (72.3%). The majority of members followed up all (60.4%) or selected (35.9%) patients after resolution o …
Corticosteroid drugs were administered systemically by 97.4%; 24.7% also injected corticosteroid intravitreally, almost always in combinatio …
Analytical approaches for assessing aggregation of protein biopharmaceuticals.
García-Fruitós E, Vazquez E, Gonzalez-Montalbán N, Ferrer-Miralles N, Villaverde A. García-Fruitós E, et al. Among authors: vazquez e. Curr Pharm Biotechnol. 2011 Oct;12(10):1530-6. doi: 10.2174/138920111798357339. Curr Pharm Biotechnol. 2011. PMID: 21542795 Review.
Production of protein-based pharmaceuticals is a major issue in conventional pharmacology, biomedicine and nanomedicine. ...
Production of protein-based pharmaceuticals is a major issue in conventional pharmacology, biomedicine and nanomedicine. ...
Post-production protein stability: trouble beyond the cell factory.
Vazquez E, Corchero JL, Villaverde A. Vazquez E, et al. Microb Cell Fact. 2011 Aug 1;10:60. doi: 10.1186/1475-2859-10-60. Microb Cell Fact. 2011. PMID: 21806813 Free PMC article.
Being protein function a conformation-dependent issue, avoiding aggregation during production is a major challenge in biotechnological processes, what is often successfully addressed by convenient upstream, midstream or downstream approaches. Even when obtained in soluble …
Being protein function a conformation-dependent issue, avoiding aggregation during production is a major challenge in biotechnologica …
Specification of DNA replication origins and genomic base composition in fission yeasts.
Mojardín L, Vázquez E, Antequera F. Mojardín L, et al. Among authors: vazquez e. J Mol Biol. 2013 Nov 29;425(23):4706-13. doi: 10.1016/j.jmb.2013.09.023. Epub 2013 Oct 3. J Mol Biol. 2013. PMID: 24095860 Review.
In the "Replicon Theory", Jacob, Brenner and Cuzin proposed the existence of replicators and initiators as the two major actors in DNA replication. Over the years, many protein components of initiators have been shown to be conserved in different organisms during evolution …
In the "Replicon Theory", Jacob, Brenner and Cuzin proposed the existence of replicators and initiators as the two major actors in DN …
Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.
Sánchez-García L, Serna N, Álamo P, Sala R, Céspedes MV, Roldan M, Sánchez-Chardi A, Unzueta U, Casanova I, Mangues R, Vázquez E, Villaverde A. Sánchez-García L, et al. Among authors: vazquez e. J Control Release. 2018 Mar 28;274:81-92. doi: 10.1016/j.jconrel.2018.01.031. Epub 2018 Jan 31. J Control Release. 2018. PMID: 29408658
Loading capacity and drug leakage from vehicles during circulation in blood is a major concern when developing nanoparticle-based cell-targeted cytotoxics. ...
Loading capacity and drug leakage from vehicles during circulation in blood is a major concern when developing nanoparticle-based cel …
Engineering protein self-assembling in protein-based nanomedicines for drug delivery and gene therapy.
Ferrer-Miralles N, Rodríguez-Carmona E, Corchero JL, García-Fruitós E, Vázquez E, Villaverde A. Ferrer-Miralles N, et al. Among authors: vazquez e. Crit Rev Biotechnol. 2015 Jun;35(2):209-21. doi: 10.3109/07388551.2013.833163. Epub 2013 Oct 9. Crit Rev Biotechnol. 2015. PMID: 24102113 Review.
Lack of targeting and improper biodistribution are major flaws in current drug-based therapies that prevent reaching high local concentrations of the therapeutic agent. ...
Lack of targeting and improper biodistribution are major flaws in current drug-based therapies that prevent reaching high local conce …
46 results