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Page 1
Bile acid analogues are activators of pyrin inflammasome.
Alimov I, Menon S, Cochran N, Maher R, Wang Q, Alford J, Concannon JB, Yang Z, Harrington E, Llamas L, Lindeman A, Hoffman G, Schuhmann T, Russ C, Reece-Hoyes J, Canham SM, Cai X. Alimov I, et al. Among authors: cai x. J Biol Chem. 2019 Mar 8;294(10):3359-3366. doi: 10.1074/jbc.RA118.005103. Epub 2019 Jan 15. J Biol Chem. 2019. PMID: 30647128 Free PMC article.
A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism.
Ptacin JL, Ma L, Caffaro CE, Acuff NV, Germar K, Severy P, Qu Y, Vela JL, Cai X, San Jose KM, Aerni HR, Chen DB, Esche E, Ismaili TK, Herman R, Pavlova Y, Pena MJ, Nguyen J, Koriazova LK, Shawver LK, Joseph IB, Mooney J, Peakman M, Milla ME. Ptacin JL, et al. Among authors: cai x. Commun Med (Lond). 2024 Mar 26;4(1):58. doi: 10.1038/s43856-024-00485-z. Commun Med (Lond). 2024. PMID: 38532017 Free PMC article.
PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.
Cai X, Xu Y, Cheung AK, Tomlinson RC, Alcázar-Román A, Murphy L, Billich A, Zhang B, Feng Y, Klumpp M, Rondeau JM, Fazal AN, Wilson CJ, Myer V, Joberty G, Bouwmeester T, Labow MA, Finan PM, Porter JA, Ploegh HL, Baird D, De Camilli P, Tallarico JA, Huang Q. Cai X, et al. Chem Biol. 2013 Jul 25;20(7):912-21. doi: 10.1016/j.chembiol.2013.05.010. Chem Biol. 2013. PMID: 23890009 Free PMC article.