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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
2000 3
2001 1
2002 2
2003 2
2004 2
2005 2
2006 3
2007 4
2008 3
2009 4
2010 8
2011 6
2012 6
2013 10
2014 10
2015 12
2016 11
2017 15
2018 10
2019 6
2020 11
2021 22
2022 14
2023 13
2024 11

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163 results

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Page 1
Global identification of SWI/SNF targets reveals compensation by EP400.
Martin BJE, Ablondi EF, Goglia C, Mimoso CA, Espinel-Cabrera PR, Adelman K. Martin BJE, et al. Cell. 2023 Nov 22;186(24):5290-5307.e26. doi: 10.1016/j.cell.2023.10.006. Epub 2023 Nov 2. Cell. 2023. PMID: 37922899
Here, we leverage a fast-acting inhibitor of SWI/SNF remodeling to elucidate direct targets and effects of SWI/SNF. Blocking SWI/SNF activity causes a rapid and global loss of chromatin accessibility and transcription. ...
Here, we leverage a fast-acting inhibitor of SWI/SNF remodeling to elucidate direct targets and effects of SWI/SNF. Blocking SWI/SNF …
Decoding the building blocks of life.
O'Leary K. O'Leary K. Nat Med. 2021 Dec;27(12):2057. doi: 10.1038/s41591-021-01613-1. Nat Med. 2021. PMID: 34907380 No abstract available.
Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy.
Tajan M, Hennequart M, Cheung EC, Zani F, Hock AK, Legrave N, Maddocks ODK, Ridgway RA, Athineos D, Suárez-Bonnet A, Ludwig RL, Novellasdemunt L, Angelis N, Li VSW, Vlachogiannis G, Valeri N, Mainolfi N, Suri V, Friedman A, Manfredi M, Blyth K, Sansom OJ, Vousden KH. Tajan M, et al. Nat Commun. 2021 Jan 14;12(1):366. doi: 10.1038/s41467-020-20223-y. Nat Commun. 2021. PMID: 33446657 Free PMC article.
In vitro, inhibition of PHGDH combined with serine starvation leads to a defect in global protein synthesis, which blocks the activation of an ATF-4 response and more broadly impacts the protective stress response to amino acid depletion. ...
In vitro, inhibition of PHGDH combined with serine starvation leads to a defect in global protein synthesis, which blocks the activat …
A Review of Regional Anesthesia in Infants.
Boretsky KR. Boretsky KR. Paediatr Drugs. 2019 Dec;21(6):439-449. doi: 10.1007/s40272-019-00360-8. Paediatr Drugs. 2019. PMID: 31628666 Review.
Regional anesthesia can prevent long-term behavioral responses to pain. As a result, the overall number and variety of nerve blocks being used in infants is increasing. While neuraxial blocks are the most common blocks performed in infants, the introduction o …
Regional anesthesia can prevent long-term behavioral responses to pain. As a result, the overall number and variety of nerve blocks b …
Portal Vein Thrombosis.
Samant H, Asafo-Agyei KO, Kimyaghalam A, Garfield K. Samant H, et al. 2024 Apr 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2024 Apr 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30480933 Free Books & Documents.
Portal vein thrombosis (PVT) is a narrowing or blocking of the portal vein by a blood clot. Thrombosis can develop in the main body of the portal vein or its intrahepatic branches and may even extend to the splenic or superior mesenteric veins. ...
Portal vein thrombosis (PVT) is a narrowing or blocking of the portal vein by a blood clot. Thrombosis can develop in the main body o …
Pernicious Anemia (Nursing).
Vaqar S, Shackelford KB, Rudolph S. Vaqar S, et al. 2023 May 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 May 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 33760459 Free Books & Documents.
These antibodies lead to the destruction of gastric parietal cells or prevent the absorption of vitamin B12 by blocking IF binding sites for this vitamin. As a result, vitamin B12 cannot be absorbed from the alimentary canal, and vitamin B12-associated megaloblastic anemia …
These antibodies lead to the destruction of gastric parietal cells or prevent the absorption of vitamin B12 by blocking IF binding si …
The big picture: exploring the metabolic cross-talk in cancer.
Schulze A, Yuneva M. Schulze A, et al. Dis Model Mech. 2018 Aug 24;11(8):dmm036673. doi: 10.1242/dmm.036673. Dis Model Mech. 2018. PMID: 30154190 Free PMC article.
Initially, this research focussed on identifying the metabolic processes that provided cancer cells with building blocks for growth or to prevent oxidative damage and death. In addition to providing detailed insight into the mechanisms by which oncogenic signalling pathway …
Initially, this research focussed on identifying the metabolic processes that provided cancer cells with building blocks for growth o …
Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.
Jin L, Garcia J, Chan E, de la Cruz C, Segal E, Merchant M, Kharbanda S, Raisner R, Haverty PM, Modrusan Z, Ly J, Choo E, Kaufman S, Beresini MH, Romero FA, Magnuson S, Gascoigne KE. Jin L, et al. Cancer Res. 2017 Oct 15;77(20):5564-5575. doi: 10.1158/0008-5472.CAN-17-0314. Epub 2017 Aug 17. Cancer Res. 2017. PMID: 28819026
To exploit this vulnerability, we developed a novel small-molecule inhibitor of the CBP/p300 bromodomain that blocks prostate cancer growth in vitro and in vivo Molecular dissection of the consequences of drug treatment revealed a critical role for CBP/p300 in histone acet …
To exploit this vulnerability, we developed a novel small-molecule inhibitor of the CBP/p300 bromodomain that blocks prostate cancer …
Dynamic altruistic cooperation within breast tumors.
Masroni MSB, Lee KW, Lee VKM, Ng SB, Law CT, Poon KS, Lee BT, Liu Z, Tan YP, Chng WL, Tucker S, Ngo LS, Yip GWC, Nga ME, Hue SSS, Putti TC, Bay BH, Lin Q, Zhou L, Hartman M, Loh TP, Lakshmanan M, Lee SY, Tergaonkar V, Chua H, Lee AVH, Yeo EYM, Li MH, Chang CF, Kee Z, Tan KM, Tan SY, Koay ES, Archetti M, Leong SM. Masroni MSB, et al. Mol Cancer. 2023 Dec 14;22(1):206. doi: 10.1186/s12943-023-01896-7. Mol Cancer. 2023. PMID: 38093346 Free PMC article.
Anti-phage defence through inhibition of virion assembly.
Patel PH, Taylor VL, Zhang C, Getz LJ, Fitzpatrick AD, Davidson AR, Maxwell KL. Patel PH, et al. Nat Commun. 2024 Feb 22;15(1):1644. doi: 10.1038/s41467-024-45892-x. Nat Commun. 2024. PMID: 38388474 Free PMC article.
Tab allows the invading phage replication cycle to proceed, but blocks assembly of the phage tail, thus preventing formation of infectious virions. ...Thus, our work reveals an anti-phage defence that operates by blocking virion assembly, thereby both preventing for …
Tab allows the invading phage replication cycle to proceed, but blocks assembly of the phage tail, thus preventing formation of infec …
163 results