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Functional and miRNA regulatory characteristics of INSIG genes highlight the key role of lipid synthesis in the liver of chicken (Gallus gallus).
Yue Y, Liu Z, Zhang K, Jia Q, Wang D, Wang Z, Guo Y, Li D, Jiang R, Li Z, Tian Y, Kang X, Liu X, Li H. Yue Y, et al. Poult Sci. 2023 Feb;102(2):102380. doi: 10.1016/j.psj.2022.102380. Epub 2022 Dec 5. Poult Sci. 2023. PMID: 36571872 Free PMC article.
Then the spatiotemporal expression profiles, over-expression and knockdown assays of chicken INSIGs were conducted. Furthermore, conservation of potential miRNA binding sites in INSIGs among species were analyzed, and the miRNA biological function and regulatory rol …
Then the spatiotemporal expression profiles, over-expression and knockdown assays of chicken INSIGs were conducted. Furthermore, cons …
PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting.
Lee JH, Kang HS, Park HY, Moon YA, Kang YN, Oh BC, Song DK, Bae JH, Im SS. Lee JH, et al. Sci Rep. 2017 Aug 30;7(1):9958. doi: 10.1038/s41598-017-10523-7. Sci Rep. 2017. PMID: 28855656 Free PMC article.
The control of SREBP processing is regulated by the insulin induced gene (INSIG)2a protein, which binds SREBP to prevent SREBP translocation to the Golgi apparatus during nutrient starvation in the liver. However, the regulation of SREBP-1c processing by INSIGs duri …
The control of SREBP processing is regulated by the insulin induced gene (INSIG)2a protein, which binds SREBP to prevent SREBP transl …
Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE-/- Mice Fed with a High-Fat Diet.
Zhang Y, Ren P, Kang Q, Liu W, Li S, Li P, Liu H, Shang J, Zhang L, Gong Y, Zhou M. Zhang Y, et al. Evid Based Complement Alternat Med. 2017;2017:3121989. doi: 10.1155/2017/3121989. Epub 2017 Apr 12. Evid Based Complement Alternat Med. 2017. PMID: 28491104 Free PMC article.
The serum blood lipids and insulin levels were measured. The expressions of PAQR3, Insig-1, SCAP, SREBP-1c, IRS-1, PI3K, Akt, and mTORC-1 in the adipose tissues were determined. ...
The serum blood lipids and insulin levels were measured. The expressions of PAQR3, Insig-1, SCAP, SREBP-1c, IRS-1, PI3K, Akt, and mTO …